Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN1 | Q05586 | 10/20 | 0.84 |
| ▸ | GRIN2B | Q13224 | 10/20 | 0.84 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.53 |
| ▸ | GAA | P10253 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.45 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.45 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.45 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12576841 | 0.91 | GRIN1 (0.84) | GRIN1GRIN2BKCNH2KDM4ECYP2C9 | |
| SCHEMBL12576833 | 0.83 | GRIN1 (0.84) | GRIN1GRIN2BKCNH2 | |
| SCHEMBL7997186 | 0.77 | GRIN1 (0.76) | GRIN1GRIN2BKCNH2MEN1KMT2A | |
| SCHEMBL15445695 | 0.76 | GRIN1 (0.84) | GRIN1GRIN2BKCNH2 | |
| SCHEMBL12576823 | 0.73 | GRIN1 (0.88) | GRIN1GRIN2BKCNH2MAPT | |
| SCHEMBL12576808 | 0.72 | GRIN1 (0.52) | GRIN1GRIN2BKCNH2MAPTKDM4E | |
| SCHEMBL12576815 | 0.71 | GRIN1 (0.64) | GRIN1GRIN2BGAAMAPTMEN1 | |
| SCHEMBL12576832 | 0.70 | KMT2A (0.53) | GRIN1GRIN2BGAAMEN1KMT2A | |
| SCHEMBL9440112 | 0.70 | KDM4E (0.58) | GRIN1GRIN2BKCNH2KDM4E | |
| SCHEMBL18455366 | 0.70 | SCN9A (0.59) | MEN1KMT2ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9079852-B2 | NMDA receptor antagonists for neuroprotection | EMORY UNIVERSITY (US) | 2015-07-14 | — | — | US | disclosed |
| US-20140031363-A1 | NMDA Receptor Antagonists for Neuroprotection | LIOTTA DENNIS C (US) | 2014-01-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140031363-A1 | NMDA Receptor Antagonists for Neuroprotection | GRIN1, GRIN2C, GRIK1 | GRIN1 1/4885GRIN2B 7/4885KCNH2 135/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.