SCHEMBL15460284

SCHEMBL15460284

COc1ccc(-c2cc3c4cc(-c5ccc(C)cc5)c5c(ccc6oc7ccccc7c65)c4sc3c3ccc4oc5ccccc5c4c23)cc1

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 6/20 0.47
MAPT P10636 6/20 0.47
LMNA P02545 5/20 0.47
RAB9A P51151 4/20 0.47
MAPK1 P28482 2/20 0.47
MAOB P27338 7/20 0.45
SMN1; SMN2 Q16637 4/20 0.44
MAT2A P31153 3/20 0.44
ATM Q13315 1/20 0.43
ALDH1A1 P00352 5/20 0.43
NPC1 O15118 3/20 0.43
HPGD P15428 2/20 0.43
KCNA5 P22460 2/20 0.43
KCNH2 Q12809 2/20 0.43
TNKS O95271 1/20 0.43
TP53 P04637 1/20 0.43
GLA P06280 1/20 0.43
CYP3A4 P08684 1/20 0.43
THRB P10828 1/20 0.43
NLRP3 Q96P20 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15462987 0.95 MAOB (0.49) KDM4EMAPTLMNARAB9AMAPK1
SCHEMBL15460206 0.87 KDM4E (0.47) KDM4EMAPTLMNARAB9AMAPK1
SCHEMBL15462964 0.82 KDM4E (0.50) KDM4EMAPTLMNARAB9AMAPK1
SCHEMBL15460261 0.81 ACACA (0.48) KDM4EMAPTLMNARAB9AMAPK1
SCHEMBL15460288 0.79 MAPT (0.41) KDM4EMAPTLMNARAB9AMAOB
SCHEMBL15460214 0.79 MAPT (0.51) KDM4EMAPTLMNARAB9AMAPK1
SCHEMBL15460286 0.76 TNKS (0.33) KDM4EMAPTRAB9ASMN1; SMN2ALDH1A1
SCHEMBL15463010 0.76 ACACA (0.53) KDM4EMAPTLMNARAB9AMAPK1
SCHEMBL15460247 0.75 MAPT (0.49) KDM4EMAPTLMNARAB9AMAPK1
SCHEMBL15460328 0.73 MAPT (0.45) KDM4EMAPTLMNARAB9AMAPK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9385327-B2 Heterocyclic compound and organic light-emitting device including the same SAMSUNG DISPLAY CO., LTD. (KR) 2016-07-05 US disclosed
US-9349966-B2 2016-05-24 US disclosed
US-20140034915-A1 HETEROCYCLIC COMPOUND AND ORGANIC LIGHT-EMITTING DEVICE INCLUDING THE SAME SAMSUNG DISPLAY CO. LTD. (KR) 2014-02-06 US disclosed