Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 8/20 | 0.60 |
| ▸ | HTT | P42858 | 4/20 | 0.60 |
| ▸ | GAA | P10253 | 3/20 | 0.60 |
| ▸ | NPC1 | O15118 | 1/20 | 0.60 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.60 |
| ▸ | MAPT | P10636 | 9/20 | 0.60 |
| ▸ | MEN1 | O00255 | 2/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.57 |
| ▸ | LMNA | P02545 | 3/20 | 0.56 |
| ▸ | GALR3 | O60755 | 1/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.52 |
| ▸ | RECQL | P46063 | 1/20 | 0.52 |
| ▸ | PKM | P14618 | 1/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15462019 | 0.92 | ALDH1A1 (0.58) | ALDH1A1SMN1; SMN2HTTGAANPC1 | |
| SCHEMBL15462018 | 0.89 | MAPT (0.57) | ALDH1A1SMN1; SMN2HTTGAANPC1 | |
| SCHEMBL15462029 | 0.88 | SMN1; SMN2 (0.77) | ALDH1A1SMN1; SMN2HTTGAANPC1 | |
| SCHEMBL15462015 | 0.88 | SMN1; SMN2 (0.55) | ALDH1A1SMN1; SMN2HTTGAANPC1 | |
| SCHEMBL15462025 | 0.85 | ALDH1A1 (0.54) | ALDH1A1SMN1; SMN2HTTGAANPC1 | |
| SCHEMBL15462011 | 0.85 | SMN1; SMN2 (0.78) | ALDH1A1SMN1; SMN2HTTGAANPC1 | |
| SCHEMBL15462022 | 0.84 | ALDH1A1 (0.52) | ALDH1A1SMN1; SMN2HTTGAANPC1 | |
| SCHEMBL1617564 | 0.84 | KMT2A (0.55) | ALDH1A1SMN1; SMN2HTTGAANPC1 | |
| SCHEMBL15462017 | 0.83 | MAPT (0.51) | ALDH1A1SMN1; SMN2HTTGAANPC1 | |
| SCHEMBL15462014 | 0.83 | SMN1; SMN2 (0.64) | ALDH1A1SMN1; SMN2HTTGAANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8865720-B2 | Sulfonyl-derivatives as novel inhibitors of histone deacetylase | JANSSEN PHARMACEUTICA NV (BE) | 2014-10-21 | — | — | US | disclosed |
| US-20140038979-A1 | SULFONYL-DERIVATIVES AS NOVEL INHIBITORS OF HISTONE DEACETYLASE | JANSSEN PHARMACEUTICA NV (BE) | 2014-02-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140038979-A1 | SULFONYL-DERIVATIVES AS NOVEL INHIBITORS OF HISTONE DEACETYLASE | HDAC3, HDAC1, HDAC11 | ALDH1A1 1215/4885SMN1; SMN2 3960/4885HTT 398/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.