Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP2K1 | Q02750 | 20/20 | 0.59 |
| ▸ | MAP2K2 | P36507 | 2/20 | 0.50 |
| ▸ | SMC2 | O95347 | 1/20 | 0.50 |
| ▸ | EGFR | P00533 | 1/20 | 0.50 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.50 |
| ▸ | SMC1A | Q14683 | 1/20 | 0.50 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.50 |
| ▸ | Q6ZSR9 | Q6ZSR9 | 1/20 | 0.50 |
| ▸ | BMP2K | Q9NSY1 | 1/20 | 0.50 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.40 |
| ▸ | NQO2 | P16083 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15463478 | 0.91 | MAP2K1 (0.61) | MAP2K1MAP2K2SMC2EGFRCSNK2A2 | |
| SCHEMBL15463541 | 0.91 | MAP2K1 (0.49) | MAP2K1MAP2K2SMC2EGFRCSNK2A2 | |
| SCHEMBL15463553 | 0.89 | MAP2K1 (0.74) | MAP2K1MAP2K2ABCB11NQO2 | |
| SCHEMBL15463485 | 0.86 | MAP2K1 (0.45) | MAP2K1MAP2K2SMC2EGFRCSNK2A2 | |
| SCHEMBL393777 | 0.85 | MAP2K1 (0.80) | MAP2K1MAP2K2SMC2EGFRCSNK2A2 | |
| SCHEMBL15463501 | 0.80 | MAP2K1 (0.59) | MAP2K1MAP2K2 | |
| SCHEMBL15463508 | 0.80 | MAP2K1 (0.73) | MAP2K1MAP2K2ABCB11NQO2 | |
| SCHEMBL393664 | 0.78 | MAP2K1 (0.56) | MAP2K1MAP2K2SMC2EGFRCSNK2A2 | |
| SCHEMBL391656 | 0.77 | MAP2K1 (0.83) | MAP2K1MAP2K2SMC2EGFRCSNK2A2 | |
| SCHEMBL15463504 | 0.76 | MAP2K1 (0.72) | MAP2K1MAP2K2ABCB11NQO2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2251327-B1 | HETEROCYCLIC INHIBITORS OF MEK | ARRAY BIOPHARMA INC (US) | 2014-02-12 | — | — | EP | claimed |