Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP2K1 | Q02750 | 16/20 | 0.49 |
| ▸ | MAP2K2 | P36507 | 3/20 | 0.40 |
| ▸ | SMC2 | O95347 | 1/20 | 0.40 |
| ▸ | EGFR | P00533 | 1/20 | 0.40 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.40 |
| ▸ | SMC1A | Q14683 | 1/20 | 0.40 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.40 |
| ▸ | Q6ZSR9 | Q6ZSR9 | 1/20 | 0.40 |
| ▸ | BMP2K | Q9NSY1 | 1/20 | 0.40 |
| ▸ | CSF1R | P07333 | 1/20 | 0.35 |
| ▸ | MAP2K5 | Q13163 | 1/20 | 0.35 |
| ▸ | EIF2AK1 | Q9BQI3 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | GALR3 | O60755 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15463526 | 0.91 | MAP2K1 (0.59) | MAP2K1MAP2K2SMC2EGFRCSNK2A2 | |
| SCHEMBL388146 | 0.85 | MAP2K1 (0.68) | MAP2K1MAP2K2SMC2EGFRCSNK2A2 | |
| SCHEMBL15463478 | 0.83 | MAP2K1 (0.61) | MAP2K1MAP2K2SMC2EGFRCSNK2A2 | |
| SCHEMBL15463501 | 0.81 | MAP2K1 (0.59) | MAP2K1MAP2K2MAP2K5EIF2AK1 | |
| SCHEMBL15463553 | 0.81 | MAP2K1 (0.74) | MAP2K1MAP2K2 | |
| SCHEMBL15463485 | 0.76 | MAP2K1 (0.45) | MAP2K1MAP2K2SMC2EGFRCSNK2A2 | |
| SCHEMBL392844 | 0.76 | MAP2K1 (0.80) | MAP2K1MAP2K2MAP2K5EIF2AK1 | |
| SCHEMBL393777 | 0.76 | MAP2K1 (0.80) | MAP2K1MAP2K2SMC2EGFRCSNK2A2 | |
| SCHEMBL4429029 | 0.75 | MAP2K1 (0.64) | MAP2K1MAP2K2SMC2EGFRCSNK2A2 | |
| SCHEMBL393931 | 0.75 | MAP2K1 (0.67) | MAP2K1MAP2K2SMC2EGFRCSNK2A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2251327-B1 | HETEROCYCLIC INHIBITORS OF MEK | ARRAY BIOPHARMA INC (US) | 2014-02-12 | — | — | EP | claimed |