Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR17 | Q13304 | 11/20 | 0.67 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | EGFR | P00533 | 2/20 | 0.44 |
| ▸ | SRC | P12931 | 1/20 | 0.44 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.43 |
| ▸ | FEN1 | P39748 | 1/20 | 0.41 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15463450 | 0.82 | GPR17 (0.66) | GPR17EGFR | |
| SCHEMBL15463507 | 0.82 | GPR17 (0.66) | GPR17EGFR | |
| SCHEMBL15463512 | 0.82 | GPR17 (0.66) | GPR17KDM4EALDH1A1EGFRSRC | |
| SCHEMBL18509728 | 0.81 | GPR17 (0.72) | GPR17KDM4EALDH1A1EGFRSRC | |
| SCHEMBL14739168 | 0.81 | GPR17 (1.00) | GPR17KDM4EALDH1A1 | |
| SCHEMBL15463559 | 0.81 | GPR17 (0.69) | GPR17KDM4EALDH1A1EGFRSRC | |
| SCHEMBL17044356 | 0.78 | MCL1 (0.58) | — | |
| SCHEMBL17044318 | 0.74 | MCL1 (0.56) | — | |
| SCHEMBL17044314 | 0.73 | MCL1 (0.58) | — | |
| SCHEMBL14739131 | 0.71 | GPR17 (1.00) | GPR17KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2567698-B1 | GPR 17 agonists and screening assay | UNIV BONN (DE) | 2014-02-12 | — | — | EP | claimed |