Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR17 | Q13304 | 8/20 | 0.69 |
| ▸ | PRKAG1 | P54619 | 2/20 | 0.40 |
| ▸ | PRKAA2 | P54646 | 2/20 | 0.40 |
| ▸ | PRKAB1 | Q9Y478 | 2/20 | 0.40 |
| ▸ | FBP1 | P09467 | 3/20 | 0.39 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.39 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.39 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.39 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.39 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | EGFR | P00533 | 1/20 | 0.37 |
| ▸ | SRC | P12931 | 1/20 | 0.37 |
| ▸ | PPARG | P37231 | 1/20 | 0.37 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14739748 | 0.81 | GPR17 (1.00) | GPR17FBP1KDM4EALDH1A1 | |
| SCHEMBL15463529 | 0.81 | GPR17 (0.67) | GPR17FFAR1KDM4EALDH1A1EGFR | |
| SCHEMBL15463511 | 0.75 | GPR17 (0.66) | GPR17FBP1CYP1A2CYP2C9 | |
| SCHEMBL15463476 | 0.73 | GPR17 (0.66) | GPR17FBP1 | |
| SCHEMBL15463467 | 0.73 | GPR17 (0.66) | GPR17FBP1FFAR1FFAR4EGFR | |
| SCHEMBL15463517 | 0.73 | GPR17 (0.66) | GPR17FBP1FFAR1KDM4EALDH1A1 | |
| SCHEMBL15463521 | 0.73 | GPR17 (0.66) | GPR17FBP1KDM4EALDH1A1HSD17B10 | |
| SCHEMBL14739900 | 0.70 | GPR17 (0.62) | GPR17ALDH1A1CYP1A2CYP2C9PTPN1 | |
| SCHEMBL15463507 | 0.68 | GPR17 (0.66) | GPR17EGFR | |
| SCHEMBL15463512 | 0.68 | GPR17 (0.66) | GPR17KDM4EALDH1A1EGFRSRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2567698-B1 | GPR 17 agonists and screening assay | UNIV BONN (DE) | 2014-02-12 | — | — | EP | claimed |