SCHEMBL15465310

SCHEMBL15465310

Cn1nccc1[C@H]1CCC[C@@H]1Oc1cc(F)c(S(=O)(=O)Nc2ccncn2)cc1Cl

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
SCN9A Q15858 20/20 1.00
SCN2B O60939 16/20 1.00
SCN1B Q07699 16/20 1.00
SCN5A Q14524 6/20 0.97
CYP3A4 P08684 2/20 0.97
CYP2C9 P11712 2/20 0.97
SCN2A Q99250 1/20 0.97
SCN8A Q9UQD0 1/20 0.97
SCN1A P35498 7/20 0.84
KCNH2 Q12809 2/20 0.81

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Ds-1971 SCHEMBL15464508 0.98 SCN9A (1.00) SCN9ASCN2BSCN1BSCN5ACYP3A4
Ds-1971 SCHEMBL15465719 0.98 SCN9A (1.00) SCN9ASCN2BSCN1BSCN5ACYP3A4
Ds-1971 SCHEMBL15465231 0.98 SCN9A (1.00) SCN9ASCN2BSCN1BSCN5ACYP3A4
Ds-1971 SCHEMBL19718340 0.98 SCN9A (1.00) SCN9ASCN2BSCN1BSCN5ACYP3A4
Ds-1971 SCHEMBL15464513 0.98 SCN9A (1.00) SCN9ASCN2BSCN1BSCN5ACYP3A4
Ds-1971 SCHEMBL16290250 0.98 SCN9A (1.00) SCN9ASCN2BSCN1BSCN5ACYP3A4
SCHEMBL15465578 0.98 SCN9A (0.98) SCN9ASCN2BSCN1BSCN5ACYP3A4
Ds-1971 SCHEMBL15471533 0.93 SCN9A (0.90) SCN9ASCN2BSCN1BSCN5ACYP3A4
SCHEMBL15465609 0.93 SCN9A (1.00) SCN9ASCN2BSCN1BSCN5ACYP3A4
SCHEMBL18230839 0.93 SCN9A (1.00) SCN9ASCN2BSCN1BSCN5ACYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 32 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2974730-B1 DRUG FOR RESPIRATORY DISEASES DAIICHI SANKYO CO LTD (JP) 2018-01-31 EP disclosed
EP-2974730-B1 DRUG FOR RESPIRATORY DISEASES DAIICHI SANKYO CO LTD (JP) 2018-01-31 EP disclosed
EP-3144300-B1 METHODS OF PRODUCING 4-CYCLOALKYLOXYBENZENESULFONAMIDES DAIICHI SANKYO CO LTD (JP) 2017-12-20 EP disclosed
EP-3144300-B1 METHODS OF PRODUCING 4-CYCLOALKYLOXYBENZENESULFONAMIDES DAIICHI SANKYO CO LTD (JP) 2017-12-20 EP disclosed
US-9845313-B2 Cycloalkane derivatives DAIICHI SANKYO COMPANY, LIMITED (JP) 2017-12-19 US disclosed
US-9845313-B2 Cycloalkane derivatives DAIICHI SANKYO COMPANY, LIMITED (JP) 2017-12-19 US disclosed
US-9845313-B2 Cycloalkane derivatives DAIICHI SANKYO COMPANY, LIMITED (JP) 2017-12-19 US disclosed
EP-3144300-A1 METHODS OF PRODUCING 4-CYCLOALKYLOXYBENZENESULFONAMIDES Daiichi Sankyo Company, Limited (JP) 2017-03-22 EP disclosed
US-9597330-B2 Drugs for treating respiratory diseases DAIICHI SANKYO COMPANY, LIMITED (JP) 2017-03-21 US disclosed
US-9597330-B2 Drugs for treating respiratory diseases DAIICHI SANKYO COMPANY, LIMITED (JP) 2017-03-21 US disclosed
EP-2974730-A1 DRUG FOR RESPIRATORY DISEASES DAIICHI SANKYO COMPANY, LIMITED (JP) 2016-01-20 EP disclosed
EP-2974730-A1 DRUG FOR RESPIRATORY DISEASES DAIICHI SANKYO COMPANY, LIMITED (JP) 2016-01-20 EP disclosed
EP-2813491-A1 CYCLOALKANE DERIVATIVE Daiichi Sankyo Co., Ltd. (JP) 2014-12-17 EP disclosed
US-8889741-B2 Cycloalkane derivatives DAIICHI SANKYO COMPANY, LIMITED (JP) 2014-11-18 US disclosed
US-8889741-B2 Cycloalkane derivatives DAIICHI SANKYO COMPANY, LIMITED (JP) 2014-11-18 US disclosed
US-8889741-B2 Cycloalkane derivatives DAIICHI SANKYO COMPANY, LIMITED (JP) 2014-11-18 US disclosed
WO-2014142221-A1 DRUG FOR RESPIRATORY DISEASES 第一三共株式会社 (JP) 2014-09-18 WO disclosed
US-20140045862-A1 Cycloalkane Derivatives DAIICHI SANKYO COMPANY, LIMITED (JP) 2014-02-13 US disclosed
US-20140045862-A1 Cycloalkane Derivatives DAIICHI SANKYO COMPANY, LIMITED (JP) 2014-02-13 US disclosed
US-20140045862-A1 Cycloalkane Derivatives DAIICHI SANKYO COMPANY, LIMITED (JP) 2014-02-13 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20140045862-A1 Cycloalkane Derivatives TRPV1, TRPA1, SCNN1A SCN9A 64/4885SCN2B 21/4885SCN1B 5/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.