Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 13/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 12/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.56 |
| ▸ | GAA | P10253 | 5/20 | 0.51 |
| ▸ | TSHR | P16473 | 5/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 4/20 | 0.51 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.44 |
| ▸ | GLA | P06280 | 3/20 | 0.42 |
| ▸ | HPGD | P15428 | 4/20 | 0.41 |
| ▸ | CA12 | O43570 | 2/20 | 0.41 |
| ▸ | CA9 | Q16790 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.40 |
| ▸ | MEN1 | O00255 | 4/20 | 0.40 |
| ▸ | LMNA | P02545 | 4/20 | 0.40 |
| ▸ | MAPT | P10636 | 4/20 | 0.40 |
| ▸ | HTT | P42858 | 3/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8298416 | 0.84 | ALDH1A1 (0.72) | ALDH1A1KDM4ESMN1; SMN2GAATSHR | |
| SCHEMBL15472029 | 0.84 | NPC1 (0.43) | ALDH1A1KDM4ESMN1; SMN2GAANPSR1 | |
| SCHEMBL9920465 | 0.77 | ALDH1A1 (0.65) | ALDH1A1KDM4ESMN1; SMN2GAATSHR | |
| SCHEMBL9904172 | 0.73 | KDM4E (0.48) | ALDH1A1KDM4ESMN1; SMN2TSHRRXFP1 | |
| SCHEMBL14541242 | 0.70 | CA12 (0.58) | ALDH1A1KDM4ESMN1; SMN2GAATSHR | |
| SCHEMBL9919755 | 0.70 | KDM4E (0.47) | ALDH1A1KDM4ESMN1; SMN2GAATSHR | |
| SCHEMBL9920906 | 0.68 | ALDH1A1 (0.50) | ALDH1A1KDM4ESMN1; SMN2TSHRRXFP1 | |
| SCHEMBL9904158 | 0.68 | ALDH1A1 (0.57) | ALDH1A1KDM4ESMN1; SMN2GAATSHR | |
| SCHEMBL30539321 | 0.67 | NOTUM (0.51) | ALDH1A1SMN1; SMN2GLAMAPT | |
| SCHEMBL11462931 | 0.67 | KMT2A (0.60) | ALDH1A1SMN1; SMN2TSHRRXFP1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9840515-B2 | Protein kinase D inhibitors | University of Pittsburgh—of the Commonwealth System of Higher Education (US) | 2017-12-12 | — | — | US | disclosed |
| US-9840515-B2 | Protein kinase D inhibitors | University of Pittsburgh—of the Commonwealth System of Higher Education (US) | 2017-12-12 | — | — | US | disclosed |
| US-20140045821-A1 | PROTEIN KINASE D INHIBITORS | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION | 2014-02-13 | — | — | US | disclosed |
| US-20140045821-A1 | PROTEIN KINASE D INHIBITORS | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION | 2014-02-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140045821-A1 | PROTEIN KINASE D INHIBITORS | PRKCD, PRKD1, PRKD2 | ALDH1A1 4548/4885KDM4E 1875/4885SMN1; SMN2 4309/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.