Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 18/20 | 0.44 |
| ▸ | CSNK1D | P48730 | 3/20 | 0.40 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.40 |
| ▸ | MAPK13 | O15264 | 3/20 | 0.38 |
| ▸ | MAPK12 | P53778 | 3/20 | 0.38 |
| ▸ | MAPK11 | Q15759 | 3/20 | 0.38 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.36 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.36 |
| ▸ | PRKACA | P17612 | 2/20 | 0.36 |
| ▸ | CSNK1A1 | P48729 | 2/20 | 0.36 |
| ▸ | MINK1 | Q8N4C8 | 2/20 | 0.36 |
| ▸ | MAP4K5 | Q9Y4K4 | 2/20 | 0.36 |
| ▸ | HSPB1 | P04792 | 1/20 | 0.36 |
| ▸ | PRKCB | P05771 | 1/20 | 0.36 |
| ▸ | PRKCA | P17252 | 1/20 | 0.36 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.35 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.35 |
| ▸ | PRKCG | P05129 | 1/20 | 0.35 |
| ▸ | LCK | P06239 | 1/20 | 0.35 |
| ▸ | LYN | P07948 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1639224 | 0.78 | MAPK14 (0.69) | MAPK14CSNK1DCSNK1EMAPK13MAPK12 | |
| SCHEMBL1640366 | 0.77 | MAPK14 (0.56) | MAPK14CSNK1DCSNK1EMAPK13MAPK12 | |
| SCHEMBL1639181 | 0.77 | MAPK14 (0.56) | MAPK14CSNK1DCSNK1EMAPK13MAPK12 | |
| SCHEMBL1641065 | 0.77 | MAPK14 (0.56) | MAPK14CSNK1DCSNK1EMAPK13MAPK12 | |
| SCHEMBL1639953 | 0.61 | CSNK1D (0.77) | MAPK14CSNK1DCSNK1EMAPK13MAPK12 | |
| SCHEMBL7607019 | 0.60 | MAPK14 (0.69) | MAPK14CSNK1DCSNK1EMAPK13MAPK12 | |
| SCHEMBL27441160 | 0.60 | MAPK14 (1.00) | MAPK14CSNK1DCSNK1EMAPK13MAPK12 | |
| SCHEMBL4915665 | 0.60 | MAPK14 (0.80) | MAPK14CSNK1DCSNK1EMAPK13MAPK12 | |
| SCHEMBL29135096 | 0.59 | MAPK14 (0.56) | MAPK14CSNK1DCSNK1EMAPK13MAPK12 | |
| SCHEMBL21428965 | 0.59 | MAPK14 (0.59) | MAPK14CSNK1DCSNK1EMAPK13MAPK12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2493876-B1 | IMIDAZOLE DERIVATIVES AS CASEIN KINASE INHIBITORS | PFIZER (US) | 2014-02-12 | — | — | EP | disclosed |