Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.47 |
| ▸ | MAPT | P10636 | 4/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | BLM | P54132 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.46 |
| ▸ | RAD52 | P43351 | 1/20 | 0.46 |
| ▸ | CXCR4 | P61073 | 5/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | TP53 | P04637 | 2/20 | 0.44 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.44 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.44 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.44 |
| ▸ | RELA | Q04206 | 2/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | BRD4 | O60885 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12767598 | 0.81 | CXCR4 (0.44) | KDM4EMAPTKMT2ASMN1; SMN2MEN1 | |
| SCHEMBL19464251 | 0.80 | KDM4E (0.59) | KDM4EMAPTSMN1; SMN2NPC1BLM | |
| SCHEMBL12766996 | 0.77 | HRH1 (0.40) | KDM4EMAPTKMT2ASMN1; SMN2MEN1 | |
| SCHEMBL14371569 | 0.77 | ALDH1A1 (0.52) | KDM4EMAPTKMT2ASMN1; SMN2MEN1 | |
| SCHEMBL13512585 | 0.75 | KDM4E (0.61) | KDM4EKMT2ASMN1; SMN2L3MBTL1ALDH1A1 | |
| SCHEMBL12424275 | 0.74 | SCN5A (0.45) | ACHEBCHECYP2C19HIF1AATM | |
| SCHEMBL16888834 | 0.73 | ATM (0.68) | KDM4EKMT2AMEN1CXCR4ALDH1A1 | |
| SCHEMBL14032714 | 0.71 | ALDH1A1 (0.56) | CXCR4ALDH1A1BRD4ATM | |
| SCHEMBL6211339 | 0.71 | NR2F2 (0.47) | KDM4EMAPTKMT2ASMN1; SMN2NPC1 | |
| SCHEMBL5778746 | 0.71 | CXCR4 (0.46) | KDM4EMAPTKMT2ASMN1; SMN2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2493876-B1 | IMIDAZOLE DERIVATIVES AS CASEIN KINASE INHIBITORS | PFIZER (US) | 2014-02-12 | — | — | EP | disclosed |