Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR9 | Q9NR96 | 6/20 | 0.41 |
| ▸ | TLR8 | Q9NR97 | 6/20 | 0.41 |
| ▸ | TLR7 | Q9NYK1 | 6/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | JAK2 | O60674 | 2/20 | 0.38 |
| ▸ | JAK1 | P23458 | 2/20 | 0.38 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.36 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.36 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.36 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | PDE9A | O76083 | 1/20 | 0.35 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24526042 | 0.83 | TLR9 (0.39) | TLR9TLR8TLR7MAPTRECQL | |
| SCHEMBL15214318 | 0.81 | L3MBTL1 (0.46) | TLR9TLR8TLR7MAPTRECQL | |
| SCHEMBL24491913 | 0.79 | MAPT (0.41) | TLR9TLR8TLR7MAPTRECQL | |
| SCHEMBL12425852 | 0.78 | MAPT (0.42) | TLR9TLR8TLR7MAPTRECQL | |
| SCHEMBL14375262 | 0.77 | KDM4E (0.51) | TLR9TLR8TLR7MAPTRECQL | |
| SCHEMBL12727215 | 0.77 | MAPT (0.40) | TLR9TLR8TLR7MAPTRECQL | |
| SCHEMBL12424320 | 0.77 | TLR9 (0.38) | TLR9TLR8TLR7MAPTRECQL | |
| SCHEMBL15014579 | 0.76 | TLR9 (0.39) | TLR9TLR8TLR7MAPTRECQL | |
| SCHEMBL12384487 | 0.74 | POLB (0.45) | MAPTOPRM1OPRL1KDM4E | |
| SCHEMBL12384403 | 0.74 | TLR9 (0.38) | TLR9TLR8TLR7MAPTRECQL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2493876-B1 | IMIDAZOLE DERIVATIVES AS CASEIN KINASE INHIBITORS | PFIZER (US) | 2014-02-12 | — | — | EP | disclosed |