Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP2K1 | Q02750 | 15/20 | 0.58 |
| ▸ | MAP2K2 | P36507 | 7/20 | 0.42 |
| ▸ | RAF1 | P04049 | 1/20 | 0.41 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.41 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.41 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.41 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.41 |
| ▸ | CSNK2A3 | Q8NEV1 | 1/20 | 0.41 |
| ▸ | AURKC | Q9UQB9 | 1/20 | 0.41 |
| ▸ | CAMK2A | Q9UQM7 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | P2RX3 | P56373 | 3/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL391989 | 0.90 | MAP2K1 (0.72) | MAP2K1MAP2K2RAF1PDGFRBCSNK2A2 | |
| SCHEMBL14549223 | 0.88 | MAP2K1 (0.61) | MAP2K1MAP2K2RAF1PDGFRBCSNK2A2 | |
| SCHEMBL12954658 | 0.82 | MAP2K2 (0.48) | MAP2K1MAP2K2MEN1KMT2AHTT | |
| SCHEMBL392162 | 0.78 | MAP2K1 (0.75) | MAP2K1MAP2K2RAF1PDGFRBCSNK2A2 | |
| SCHEMBL393825 | 0.77 | MAP2K1 (0.73) | MAP2K1MAP2K2RAF1PDGFRBCSNK2A2 | |
| SCHEMBL392975 | 0.77 | MAP2K1 (0.71) | MAP2K1MAP2K2 | |
| SCHEMBL14549242 | 0.76 | MAP2K1 (0.81) | MAP2K1MAP2K2RAF1PDGFRBCSNK2A2 | |
| SCHEMBL15468554 | 0.75 | MAP2K1 (0.64) | MAP2K1MAP2K2RAF1PDGFRBCSNK2A2 | |
| SCHEMBL14549255 | 0.75 | MAP2K1 (0.65) | MAP2K1MAP2K2RAF1PDGFRBCSNK2A2 | |
| SCHEMBL5179043 | 0.74 | MAP2K1 (0.68) | MAP2K1MAP2K2RAF1PDGFRBCSNK2A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2251327-B1 | HETEROCYCLIC INHIBITORS OF MEK | ARRAY BIOPHARMA INC (US) | 2014-02-12 | — | — | EP | disclosed |