Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC2A1 | P11166 | 1/20 | 0.55 |
| ▸ | DRD2 | P14416 | 10/20 | 0.50 |
| ▸ | DRD3 | P35462 | 8/20 | 0.50 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.50 |
| ▸ | DRD1 | P21728 | 3/20 | 0.46 |
| ▸ | DRD4 | P21917 | 3/20 | 0.46 |
| ▸ | DRD5 | P21918 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.44 |
| ▸ | BRD1 | O95696 | 1/20 | 0.44 |
| ▸ | BRPF1 | P55201 | 1/20 | 0.44 |
| ▸ | ACHE | P22303 | 1/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL1752116 | 0.99 | SLC2A1 (0.54) | SLC2A1DRD2DRD3SIGMAR1DRD1 | |
| SCHEMBL1561499 | 0.94 | DRD3 (0.59) | SLC2A1DRD2DRD3SIGMAR1DRD1 | |
| SCHEMBL1546261 | 0.88 | SLC2A1 (0.53) | SLC2A1DRD2DRD3ALDH1A1HTT | |
| SCHEMBL5574178 | 0.88 | DRD2 (0.52) | SLC2A1DRD2DRD3DRD1DRD4 | |
| SCHEMBL1545864 | 0.88 | DRD2 (0.52) | SLC2A1DRD2DRD3DRD1DRD4 | |
| SCHEMBL1545866 | 0.88 | DRD2 (0.52) | SLC2A1DRD2DRD3DRD1DRD4 | |
| Hydrochloric Acid SCHEMBL1752315 | 0.87 | SLC2A1 (0.52) | SLC2A1DRD2DRD3ALDH1A1HTT | |
| Hydrochloric Acid SCHEMBL1545751 | 0.87 | DRD2 (0.51) | SLC2A1DRD2DRD3ALDH1A1SMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL1546697 | 0.87 | DRD2 (0.51) | SLC2A1DRD2DRD3ALDH1A1SMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL1545749 | 0.87 | DRD2 (0.51) | SLC2A1DRD2DRD3ALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2311802-A1 | Heterocyclic compounds suitable for treating disorders that respond to modulation of the dopamine D3 receptor | Abbott GmbH & Co. KG (DE) | 2011-04-20 | — | — | EP | disclosed |
| EP-2311803-A1 | Heterocyclic compounds suitable for treating disorders that respond to modulation of the dopamine D3 receptor | Abbott GmbH & Co. KG (DE) | 2011-04-20 | — | — | EP | disclosed |
| EP-1814849-B1 | HETEROCYCLIC COMPOUNDS SUITABLE FOR TREATING DISORDERS THAT RESPOND TO MODULATION OF THE DOPAMINE D3 RECEPTOR | ABBOTT GMBH & CO KG (DE) | 2011-04-06 | — | — | EP | disclosed |
| EP-1814849-A1 | HETEROCYCLIC COMPOUNDS SUITABLE FOR TREATING DISORDERS THAT RESPOND TO MODULATION OF THE DOPAMINE D3 RECEPTOR | Abbott GmbH & Co. KG (DE) | 2007-08-08 | — | — | EP | disclosed |
| WO-2006040182-A1 | HETEROCYCLIC COMPOUNDS SUITABLE FOR TREATING DISORDERS THAT RESPOND TO MODULATION OF THE DOPAMINE D3 RECEPTOR | ABBOTT GMBH & CO. KG (DE) | 2006-04-20 | — | — | WO | disclosed |