Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Ceftriaxone. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1I2 | O75469 | 5/20 | 0.78 |
| ▸ | PGR | P06401 | 2/20 | 0.78 |
| ▸ | PPARG | P37231 | 2/20 | 0.78 |
| ▸ | SLC22A6 | Q4U2R8 | 2/20 | 0.78 |
| ▸ | SLC22A8 | Q8TCC7 | 2/20 | 0.78 |
| ▸ | SLC22A11 | Q9NSA0 | 2/20 | 0.78 |
| ▸ | DAO | P14920 | 1/20 | 0.78 |
| ▸ | SNCA | P37840 | 1/20 | 0.78 |
| ▸ | CYP2J2 | P51589 | 1/20 | 0.78 |
| ▸ | TDP1 | Q9NUW8 | 6/20 | 0.77 |
| ▸ | MAPT | P10636 | 5/20 | 0.77 |
| ▸ | ABCC4 | O15439 | 2/20 | 0.77 |
| ▸ | APEX1 | P27695 | 3/20 | 0.76 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.76 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.76 |
| ▸ | POLB | P06746 | 2/20 | 0.76 |
| ▸ | RECQL | P46063 | 2/20 | 0.76 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.76 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.76 |
| ▸ | BLM | P54132 | 1/20 | 0.76 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Ceftriaxone SCHEMBL22635993 | 0.99 | NR1I2 (0.79) | NR1I2PGRPPARGSLC22A6SLC22A8 | |
| Ceftriaxone SCHEMBL150106 | 0.99 | NR1I2 (0.79) | NR1I2PGRPPARGSLC22A6SLC22A8 | |
| Ceftriaxone SCHEMBL40849 | 0.99 | NR1I2 (0.79) | NR1I2PGRPPARGSLC22A6SLC22A8 | |
| Ceftriaxone SCHEMBL8378294 | 0.99 | NR1I2 (0.80) | NR1I2PGRPPARGSLC22A6SLC22A8 | |
| Ceftriaxone SCHEMBL2224183 | 0.99 | NR1I2 (0.80) | NR1I2PGRPPARGSLC22A6SLC22A8 | |
| Ceftriaxone SCHEMBL23354 | 0.99 | NR1I2 (0.80) | NR1I2PGRPPARGSLC22A6SLC22A8 | |
| Ceftriaxone SCHEMBL2006478 | 0.99 | NR1I2 (0.80) | NR1I2PGRPPARGSLC22A6SLC22A8 | |
| Ceftriaxone SCHEMBL4897101 | 0.99 | NR1I2 (0.80) | NR1I2PGRPPARGSLC22A6SLC22A8 | |
| Ceftriaxone SCHEMBL30307091 | 0.99 | NR1I2 (0.80) | NR1I2PGRPPARGSLC22A6SLC22A8 | |
| Ceftriaxone SCHEMBL2006477 | 0.99 | NR1I2 (0.80) | NR1I2PGRPPARGSLC22A6SLC22A8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180042899-A1 | Method of Treating Transplant Rejection and Autoimmune Diseases | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2018-02-15 | — | — | US | disclosed |
| US-20140050694-A1 | Method of Treating Transplant Rejection and Autoimmune Diseases | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 2014-02-20 | — | — | US | disclosed |