Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Ceftriaxone. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1I2 | O75469 | 6/20 | 0.79 |
| ▸ | PGR | P06401 | 3/20 | 0.79 |
| ▸ | PPARG | P37231 | 2/20 | 0.79 |
| ▸ | SLC22A6 | Q4U2R8 | 2/20 | 0.79 |
| ▸ | SLC22A8 | Q8TCC7 | 2/20 | 0.79 |
| ▸ | SLC22A11 | Q9NSA0 | 2/20 | 0.79 |
| ▸ | DAO | P14920 | 1/20 | 0.79 |
| ▸ | SNCA | P37840 | 1/20 | 0.79 |
| ▸ | CYP2J2 | P51589 | 1/20 | 0.79 |
| ▸ | ABCC4 | O15439 | 2/20 | 0.78 |
| ▸ | TDP1 | Q9NUW8 | 6/20 | 0.77 |
| ▸ | MAPT | P10636 | 5/20 | 0.77 |
| ▸ | APEX1 | P27695 | 3/20 | 0.77 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.77 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.77 |
| ▸ | POLB | P06746 | 2/20 | 0.77 |
| ▸ | RECQL | P46063 | 2/20 | 0.77 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.77 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.77 |
| ▸ | BLM | P54132 | 1/20 | 0.77 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Ceftriaxone SCHEMBL150106 | 1.00 | NR1I2 (0.79) | NR1I2PGRPPARGSLC22A6SLC22A8 | |
| Ceftriaxone SCHEMBL15475285 | 0.99 | NR1I2 (0.78) | NR1I2PGRPPARGSLC22A6SLC22A8 | |
| Ceftriaxone SCHEMBL2224183 | 0.99 | NR1I2 (0.80) | NR1I2PGRPPARGSLC22A6SLC22A8 | |
| Ceftriaxone SCHEMBL8378294 | 0.99 | NR1I2 (0.80) | NR1I2PGRPPARGSLC22A6SLC22A8 | |
| Ceftriaxone SCHEMBL2006477 | 0.99 | NR1I2 (0.80) | NR1I2PGRPPARGSLC22A6SLC22A8 | |
| Ceftriaxone SCHEMBL23354 | 0.99 | NR1I2 (0.80) | NR1I2PGRPPARGSLC22A6SLC22A8 | |
| Ceftriaxone SCHEMBL2006478 | 0.99 | NR1I2 (0.80) | NR1I2PGRPPARGSLC22A6SLC22A8 | |
| Ceftriaxone SCHEMBL4897101 | 0.99 | NR1I2 (0.80) | NR1I2PGRPPARGSLC22A6SLC22A8 | |
| Ceftriaxone SCHEMBL30307091 | 0.99 | NR1I2 (0.80) | NR1I2PGRPPARGSLC22A6SLC22A8 | |
| Ceftriaxone SCHEMBL8619948 | 0.99 | NR1I2 (0.80) | NR1I2PGRPPARGSLC22A6SLC22A8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 5838 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116836182-B | Integral recovery method of active ingredients in ceftriaxone sodium crystal acetone mother liquor | 国药集团威奇达药业有限公司 | 2026-05-15 | — | — | CN | claimed |
| CN-122031482-A | Application of ceftriaxone sodium in preparing medicament for preventing and/or treating pulmonary nodules | 郑州大学 | 2026-05-15 | — | — | CN | claimed |
| CN-121550436-B | Composition and combination mode | 四川大学华西医院 | 2026-05-12 | — | — | CN | claimed |
| CN-120131670-A | Antibiotic nano enzyme for reversing drug resistance | 中原纳米酶实验室 | 2025-06-13 | — | — | CN | claimed |
| WO-2025111413-A1 | TREATMENT FOR SKIN DISORDERS | Mycotechnology, Inc. (US) | 2025-05-30 | — | — | WO | claimed |
| CN-119792226-B | Whole-body antibacterial capsule and production process thereof | 北京京丰制药集团有限公司 | 2025-05-23 | — | — | CN | claimed |
| CN-119972136-A | Manganese doped carbon quantum dot/molybdenum oxide composite photocatalyst and preparation method and application thereof | 武汉工程大学 | 2025-05-13 | — | — | CN | claimed |
| CN-119955688-A | Slightly acidophilic oligotrophic Monomonas and application thereof | 合成生物学海河实验室 | 2025-05-09 | — | — | CN | claimed |
| US-20250144187-A1 | COMBINATION OF HYDROLASES AND ANTI-MICROORGANISM DRUGS AND USES THEREOF | Centre for Eye and Vision Research Limited (CN) | 2025-05-08 | — | — | US | claimed |
| CN-119915916-A | Method for determining impurities in ceftriaxone sodium for injection | 上海上药新亚药业有限公司 | 2025-05-02 | — | — | CN | claimed |
| CN-1404834-A | Antibiotics composition with synergistic effect to generation of beta lactamase medicine-resisting strain | ZHONG YUGUO (CN) | 2003-03-26 | — | — | CN | claimed |
| WO-2003015757-A1 | SYNTHESIS AND USE OF REAGENTS FOR IMPROVED DNA LIPOFECTION AND/OR SLOW RELEASE PRODRUG AND DRUG THERAPIES | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2003-02-27 | — | — | WO | claimed |
| US-6406717-B2 | Rapid-melt semi-solid compositions, methods of making same and methods of using same | CAPRICORN PHARMA, INC. | 2002-06-18 | — | — | US | claimed |
| WO-2002030469-A2 | BETA-LACTAM ANTIBIOTIC-POLYSACCHARIDE COMPLEX | ORCHID CHEMICALS AND PHARMACEUTICALS LIMITED (IN) | 2002-04-18 | — | — | WO | claimed |
| US-20020004071-A1 | Rapid-melt semi-solid compositions, methods of making same and methods of using same | CAPRICORN PHARMA, INC. | 2002-01-10 | — | — | US | claimed |
| WO-2002002080-A1 | RAPID-MELT SEMI-SOLID COMPOSITIONS, METHODS OF MAKING SAME AND METHODS OF USING SAME | CAPRICORN PHARMA, INC. (US) | 2002-01-10 | — | — | WO | claimed |
| US-6245735-B1 | CONJUGATE OF ANTIBIOTIC AND POLYPEPTIDE OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR OR LIPOPOLYSACCHARIDE BINDING FRAGMENT | THE BRIGHAM AND WOMEN'S HOSPITAL, INC. | 2001-06-12 | — | — | US | claimed |
| EP-1051991-A2 | Apparatus for automatic administration of multiple doses of drugs | SARCOS, INC. (US) | 2000-11-15 | — | — | EP | claimed |
| US-6056734-A | Method for automatic dosing of drugs | SARCOS LC (US) | 2000-05-02 | — | — | US | claimed |
| US-5811547-A | Method for inducing crystalline state transition in medicinal substance | NIPPON SHINYAJU CO., LTD. (JP) | 1998-09-22 | — | — | US | claimed |