⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7009257 | 0.69 | — | — | |
| SCHEMBL10462133 | 0.61 | — | — | |
| SCHEMBL622864 | 0.56 | — | — | |
| SCHEMBL10463561 | 0.56 | — | — | |
| SCHEMBL1543593 | 0.56 | — | — | |
| SCHEMBL18658893 | 0.48 | — | — | |
| SCHEMBL812324 | 0.47 | — | — | |
| SCHEMBL14788285 | 0.47 | — | — | |
| SCHEMBL6203905 | 0.46 | TYR (0.55) | — | |
| SCHEMBL3234036 | 0.46 | GABRA1 (0.43) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2895489-B1 | NOVEL INHIBITOR COMPOUNDS OF PHOSPHODIESTERASE TYPE 10A | ABBVIE DEUTSCHLAND (DE) | 2017-10-18 | — | — | EP | disclosed |
| EP-2885299-B1 | INHIBITOR COMPOUNDS OF PHOSPHODIESTERASE TYPE 10A | ABBVIE DEUTSCHLAND (DE) | 2017-04-05 | — | — | EP | disclosed |
| US-9464085-B2 | Inhibitor compounds of phosphodiesterase type 10A | AbbVie Deutschland GmbH & Co. KG (DE) | 2016-10-11 | — | — | US | disclosed |
| US-9388180-B2 | Inhibitor compounds of phosphodiesterase type 10A | ABBVIE INC. (US) | 2016-07-12 | — | — | US | disclosed |
| EP-2895489-A1 | NOVEL INHIBITOR COMPOUNDS OF PHOSPHODIESTERASE TYPE 10A | AbbVie Deutschland GmbH & Co. KG (DE) | 2015-07-22 | — | — | EP | disclosed |
| US-20140107126-A1 | NOVEL INHIBITOR COMPOUNDS OF PHOSPHODIESTERASE TYPE 10A | AbbVie Deutschland GmbH & Co. KG (DE) | 2014-04-17 | — | — | US | disclosed |
| WO-2014041175-A1 | NOVEL INHIBITOR COMPOUNDS OF PHOSPHODIESTERASE TYPE 10A | ABBOTT GMBH & CO. KG (DE) | 2014-03-20 | — | — | WO | disclosed |
| US-20140051695-A1 | NOVEL INHIBITOR COMPOUNDS OF PHOSPHODIESTERASE TYPE 10A | AbbVie Deutschland GmbH & Co. KG (DE) | 2014-02-20 | — | — | US | disclosed |