Sugi Predict

Sugi Predict / Compounds / SCHEMBL15480412

SCHEMBL15480412

SCHEMBL15480412

O=C(CCCCCCC(=O)Nc1ccc(OCc2ccccc2)cc1)NO

nearest known ligand 0.74

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ LTA4H P09960 9/20 0.74
▸ HDAC4 P56524 7/20 0.67
▸ HDAC1 Q13547 7/20 0.67
▸ HDAC7 Q8WUI4 7/20 0.67
▸ HDAC11 Q96DB2 7/20 0.67
▸ HDAC8 Q9BY41 7/20 0.67
▸ HDAC6 Q9UBN7 7/20 0.67
▸ HDAC9 Q9UKV0 7/20 0.67
▸ HDAC5 Q9UQL6 7/20 0.67
▸ HDAC3 O15379 6/20 0.67
▸ HDAC2 Q92769 6/20 0.67
▸ HDAC10 Q969S8 6/20 0.67
▸ KDM4E B2RXH2 1/20 0.67
▸ BRD4 O60885 1/20 0.67
▸ NCOR1 O75376 1/20 0.67
▸ NR1I2 O75469 1/20 0.67
▸ EGFR P00533 1/20 0.67
▸ CYP3A4 P08684 1/20 0.67
▸ NR0B1 P51843 1/20 0.67
▸ PLK1 P53350 1/20 0.67

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15480394 0.91 LTA4H (0.76) LTA4HMEN1KMT2ANPC1ALDH1A1
SCHEMBL4075780 0.90 LTA4H (0.84) LTA4HMEN1KMT2ANPC1ALDH1A1
SCHEMBL8285326 0.90 HDAC1 (0.61) LTA4HHDAC4HDAC1HDAC7HDAC11
SCHEMBL8285419 0.90 HDAC1 (0.61) LTA4HHDAC4HDAC1HDAC7HDAC11
SCHEMBL4075782 0.86 LTA4H (0.78) LTA4HKDM4EMEN1KMT2ANPC1
SCHEMBL10207293 0.86 HDAC1 (0.63) LTA4HHDAC4HDAC1HDAC7HDAC11
SCHEMBL21067844 0.85 LTA4H (1.00) LTA4HMEN1KMT2ANPC1ALDH1A1
SCHEMBL7364137 0.85 HDAC3 (0.74) LTA4HHDAC4HDAC1HDAC7HDAC11
SCHEMBL29180030 0.82 HDAC1 (0.68) LTA4HHDAC4HDAC1HDAC7HDAC11
SCHEMBL23055010 0.81 HDAC1 (1.00) LTA4HHDAC4HDAC1HDAC7HDAC11

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20210060014-A1 COMPOUNDS AND METHODS FOR IMPROVING IMPAIRED ENDOGENOUS FIBRINOLYSIS USING HISTONE DEACETYLASE INHIBITORS CERENO SCIENTIFIC AB (SE) 2021-03-04 — — US disclosed
US-20170020874-A1 COMPOUNDS AND METHODS FOR IMPROVING IMPAIRED ENDOGENOUS FIBRINOLYSIS USING HISTONE DEACETYLASE INHIBITORS CERENO SCIENT AB (SE) 2017-01-26 — — US disclosed
US-20140051716-A1 COMPOUNDS AND METHODS FOR IMPROVING IMPAIRED ENDOGENOUS FIBRINOLYSIS USING HISTONE DEACETYLASE INHIBITORS CERENO SCIENTIFIC AB 2014-02-20 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20140051716-A1 COMPOUNDS AND METHODS FOR IMPROVING IMPAIRED ENDOGENOUS FIBRINOLYSIS USING HISTONE DEACETYLASE INHIBITORS HDAC3, HDAC1, HDAC2 LTA4H 968/4885HDAC4 7/4885HDAC1 2/4885
US-20170020874-A1 COMPOUNDS AND METHODS FOR IMPROVING IMPAIRED ENDOGENOUS FIBRINOLYSIS USING HISTONE DEACETYLASE INHIBITORS HDAC3, HDAC1, HDAC2 LTA4H 968/4885HDAC4 7/4885HDAC1 2/4885
US-20210060014-A1 COMPOUNDS AND METHODS FOR IMPROVING IMPAIRED ENDOGENOUS FIBRINOLYSIS USING HISTONE DEACETYLASE INHIBITORS HDAC3, HDAC1, HDAC2 LTA4H 968/4885HDAC4 7/4885HDAC1 2/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.