Sugi Predict

Sugi Predict / Compounds / SCHEMBL15480418

SCHEMBL15480418

SCHEMBL15480418

O=C(CCCCCCC(=O)Nc1cc(F)c(F)cc1F)NO

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ HDAC1 Q13547 19/20 0.56
▸ HDAC6 Q9UBN7 17/20 0.56
▸ HDAC3 O15379 17/20 0.56
▸ HDAC2 Q92769 17/20 0.56
▸ HDAC10 Q969S8 13/20 0.56
▸ NCOR2 Q9Y618 6/20 0.56
▸ HDAC8 Q9BY41 15/20 0.51
▸ HDAC11 Q96DB2 13/20 0.51
▸ HDAC5 Q9UQL6 11/20 0.51
▸ HDAC4 P56524 10/20 0.51
▸ HDAC7 Q8WUI4 10/20 0.51
▸ HDAC9 Q9UKV0 10/20 0.51
▸ EGFR P00533 2/20 0.50
▸ KDM4E B2RXH2 1/20 0.50
▸ BRD4 O60885 1/20 0.50
▸ NCOR1 O75376 1/20 0.50
▸ NR1I2 O75469 1/20 0.50
▸ CYP3A4 P08684 1/20 0.50
▸ LTA4H P09960 1/20 0.50
▸ NR0B1 P51843 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28448765 0.87 CETP (0.57) HDAC1HDAC6HDAC3HDAC2HDAC10
SCHEMBL27943779 0.87 CETP (0.57) HDAC1HDAC6HDAC3HDAC2HDAC10
SCHEMBL15480422 0.83 HDAC1 (0.63) HDAC1HDAC6HDAC3HDAC2HDAC10
SCHEMBL15480425 0.83 HDAC1 (0.63) HDAC1HDAC6HDAC3HDAC2HDAC10
SCHEMBL31635252 0.82 HDAC1 (0.62) HDAC1HDAC6HDAC3HDAC2HDAC10
SCHEMBL27924386 0.81 HDAC3 (0.44) HDAC1HDAC6HDAC3HDAC2HDAC10
SCHEMBL8363038 0.79 HDAC1 (0.72) HDAC1HDAC6HDAC3HDAC2HDAC10
SCHEMBL8360016 0.78 HDAC1 (0.76) HDAC1HDAC6HDAC3HDAC2HDAC10
SCHEMBL28135499 0.77 MAPK1 (0.50) KDM4E
SCHEMBL15480424 0.77 HDAC1 (0.64) HDAC1HDAC6HDAC3HDAC2HDAC10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20210060014-A1 COMPOUNDS AND METHODS FOR IMPROVING IMPAIRED ENDOGENOUS FIBRINOLYSIS USING HISTONE DEACETYLASE INHIBITORS CERENO SCIENTIFIC AB (SE) 2021-03-04 — — US disclosed
US-20170020874-A1 COMPOUNDS AND METHODS FOR IMPROVING IMPAIRED ENDOGENOUS FIBRINOLYSIS USING HISTONE DEACETYLASE INHIBITORS CERENO SCIENT AB (SE) 2017-01-26 — — US disclosed
US-20140051716-A1 COMPOUNDS AND METHODS FOR IMPROVING IMPAIRED ENDOGENOUS FIBRINOLYSIS USING HISTONE DEACETYLASE INHIBITORS CERENO SCIENTIFIC AB 2014-02-20 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20140051716-A1 COMPOUNDS AND METHODS FOR IMPROVING IMPAIRED ENDOGENOUS FIBRINOLYSIS USING HISTONE DEACETYLASE INHIBITORS HDAC3, HDAC1, HDAC2 HDAC1 2/4885HDAC6 10/4885HDAC3 1/4885
US-20170020874-A1 COMPOUNDS AND METHODS FOR IMPROVING IMPAIRED ENDOGENOUS FIBRINOLYSIS USING HISTONE DEACETYLASE INHIBITORS HDAC3, HDAC1, HDAC2 HDAC1 2/4885HDAC6 10/4885HDAC3 1/4885
US-20210060014-A1 COMPOUNDS AND METHODS FOR IMPROVING IMPAIRED ENDOGENOUS FIBRINOLYSIS USING HISTONE DEACETYLASE INHIBITORS HDAC3, HDAC1, HDAC2 HDAC1 2/4885HDAC6 10/4885HDAC3 1/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.