Sugi Predict

Sugi Predict / Compounds / SCHEMBL15480424

SCHEMBL15480424

SCHEMBL15480424

O=C(CCCCCCC(=O)Nc1cc(F)c(F)c(F)c1)NO

nearest known ligand 0.64

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ HDAC1 Q13547 20/20 0.64
▸ HDAC6 Q9UBN7 20/20 0.64
▸ HDAC3 O15379 18/20 0.64
▸ HDAC2 Q92769 18/20 0.64
▸ HDAC8 Q9BY41 17/20 0.61
▸ HDAC11 Q96DB2 16/20 0.61
▸ HDAC10 Q969S8 15/20 0.61
▸ HDAC5 Q9UQL6 14/20 0.61
▸ HDAC4 P56524 13/20 0.61
▸ HDAC7 Q8WUI4 13/20 0.61
▸ HDAC9 Q9UKV0 13/20 0.61
▸ NCOR2 Q9Y618 4/20 0.58
▸ EGFR P00533 3/20 0.58
▸ KDM4E B2RXH2 1/20 0.58
▸ BRD4 O60885 1/20 0.58
▸ NCOR1 O75376 1/20 0.58
▸ NR1I2 O75469 1/20 0.58
▸ CYP3A4 P08684 1/20 0.58
▸ LTA4H P09960 1/20 0.58
▸ NR0B1 P51843 1/20 0.58

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30764853 0.85 LMNA (0.52) HDAC1HDAC6HDAC3HDAC2HDAC8
SCHEMBL15480427 0.85 HDAC1 (0.71) HDAC1HDAC6HDAC3HDAC2HDAC8
SCHEMBL8360016 0.84 HDAC1 (0.76) HDAC1HDAC6HDAC3HDAC2HDAC8
SCHEMBL31635263 0.78 HDAC1 (0.83) HDAC1HDAC6HDAC3HDAC2HDAC8
SCHEMBL11939633 0.78 HDAC1 (1.00) HDAC1HDAC6HDAC3HDAC2HDAC8
SCHEMBL26623285 0.77 TP53 (0.55) HDAC1HDAC6HDAC3HDAC2HDAC8
SCHEMBL15480434 0.77 HDAC1 (0.59) HDAC1HDAC6HDAC3HDAC2HDAC8
SCHEMBL15480418 0.77 HDAC1 (0.56) HDAC1HDAC6HDAC3HDAC2HDAC8
SCHEMBL15480421 0.77 HDAC1 (0.59) HDAC1HDAC6HDAC3HDAC2HDAC8
SCHEMBL11939084 0.76 HDAC1 (0.75) HDAC1HDAC6HDAC3HDAC2HDAC8

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20210060014-A1 COMPOUNDS AND METHODS FOR IMPROVING IMPAIRED ENDOGENOUS FIBRINOLYSIS USING HISTONE DEACETYLASE INHIBITORS CERENO SCIENTIFIC AB (SE) 2021-03-04 — — US disclosed
US-20170020874-A1 COMPOUNDS AND METHODS FOR IMPROVING IMPAIRED ENDOGENOUS FIBRINOLYSIS USING HISTONE DEACETYLASE INHIBITORS CERENO SCIENT AB (SE) 2017-01-26 — — US disclosed
US-20140051716-A1 COMPOUNDS AND METHODS FOR IMPROVING IMPAIRED ENDOGENOUS FIBRINOLYSIS USING HISTONE DEACETYLASE INHIBITORS CERENO SCIENTIFIC AB 2014-02-20 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20140051716-A1 COMPOUNDS AND METHODS FOR IMPROVING IMPAIRED ENDOGENOUS FIBRINOLYSIS USING HISTONE DEACETYLASE INHIBITORS HDAC3, HDAC1, HDAC2 HDAC1 2/4885HDAC6 10/4885HDAC3 1/4885
US-20170020874-A1 COMPOUNDS AND METHODS FOR IMPROVING IMPAIRED ENDOGENOUS FIBRINOLYSIS USING HISTONE DEACETYLASE INHIBITORS HDAC3, HDAC1, HDAC2 HDAC1 2/4885HDAC6 10/4885HDAC3 1/4885
US-20210060014-A1 COMPOUNDS AND METHODS FOR IMPROVING IMPAIRED ENDOGENOUS FIBRINOLYSIS USING HISTONE DEACETYLASE INHIBITORS HDAC3, HDAC1, HDAC2 HDAC1 2/4885HDAC6 10/4885HDAC3 1/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.