Sugi Predict

Sugi Predict / Compounds / SCHEMBL15480423

SCHEMBL15480423

SCHEMBL15480423

O=C(CCCCCCC(=O)Nc1c(F)c(F)c(F)c(F)c1F)NO

nearest known ligand 0.65

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ MEN1 O00255 1/20 0.59
▸ KMT2A Q03164 1/20 0.59
▸ HDAC1 Q13547 15/20 0.58
▸ HDAC6 Q9UBN7 14/20 0.58
▸ HDAC2 Q92769 14/20 0.58
▸ HDAC3 O15379 13/20 0.58
▸ HDAC8 Q9BY41 11/20 0.58
▸ HDAC5 Q9UQL6 10/20 0.58
▸ GAA P10253 1/20 0.56
▸ HDAC11 Q96DB2 10/20 0.53
▸ HDAC10 Q969S8 10/20 0.53
▸ HDAC4 P56524 9/20 0.53
▸ HDAC7 Q8WUI4 9/20 0.53
▸ HDAC9 Q9UKV0 9/20 0.53
▸ NCOR2 Q9Y618 3/20 0.51
▸ KDM4E B2RXH2 1/20 0.51
▸ BRD4 O60885 1/20 0.51
▸ NCOR1 O75376 1/20 0.51
▸ NR1I2 O75469 1/20 0.51
▸ EGFR P00533 1/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15480437 0.92 MEN1 (0.67) MEN1KMT2AHDAC1HDAC6HDAC2
SCHEMBL15480420 0.81 HDAC1 (0.58) HDAC1HDAC6HDAC2HDAC3HDAC8
SCHEMBL15480421 0.79 HDAC1 (0.59) HDAC1HDAC6HDAC2HDAC3HDAC8
SCHEMBL10439098 0.76 HDAC1 (1.00) HDAC1HDAC6HDAC2HDAC3HDAC8
Suberohydroxamic Acid SCHEMBL2159033 0.76 HDAC1 (1.00) HDAC1HDAC6HDAC2HDAC3HDAC8
SCHEMBL11767258 0.76 HDAC1 (1.00) HDAC1HDAC6HDAC2HDAC3HDAC8
SCHEMBL11764904 0.76 HDAC1 (1.00) HDAC1HDAC6HDAC2HDAC3HDAC8
Azelaic Bis Hydroxamic Acid SCHEMBL4741072 0.76 HDAC1 (1.00) HDAC1HDAC6HDAC2HDAC3HDAC8
SCHEMBL11769965 0.76 HDAC1 (1.00) HDAC1HDAC6HDAC2HDAC3HDAC8
SCHEMBL15480424 0.75 HDAC1 (0.64) HDAC1HDAC6HDAC2HDAC3HDAC8

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20210060014-A1 COMPOUNDS AND METHODS FOR IMPROVING IMPAIRED ENDOGENOUS FIBRINOLYSIS USING HISTONE DEACETYLASE INHIBITORS CERENO SCIENTIFIC AB (SE) 2021-03-04 — — US disclosed
US-20170020874-A1 COMPOUNDS AND METHODS FOR IMPROVING IMPAIRED ENDOGENOUS FIBRINOLYSIS USING HISTONE DEACETYLASE INHIBITORS CERENO SCIENT AB (SE) 2017-01-26 — — US disclosed
US-20140051716-A1 COMPOUNDS AND METHODS FOR IMPROVING IMPAIRED ENDOGENOUS FIBRINOLYSIS USING HISTONE DEACETYLASE INHIBITORS CERENO SCIENTIFIC AB 2014-02-20 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20140051716-A1 COMPOUNDS AND METHODS FOR IMPROVING IMPAIRED ENDOGENOUS FIBRINOLYSIS USING HISTONE DEACETYLASE INHIBITORS HDAC3, HDAC1, HDAC2 MEN1 4342/4885KMT2A 223/4885HDAC1 2/4885
US-20170020874-A1 COMPOUNDS AND METHODS FOR IMPROVING IMPAIRED ENDOGENOUS FIBRINOLYSIS USING HISTONE DEACETYLASE INHIBITORS HDAC3, HDAC1, HDAC2 MEN1 4342/4885KMT2A 223/4885HDAC1 2/4885
US-20210060014-A1 COMPOUNDS AND METHODS FOR IMPROVING IMPAIRED ENDOGENOUS FIBRINOLYSIS USING HISTONE DEACETYLASE INHIBITORS HDAC3, HDAC1, HDAC2 MEN1 4342/4885KMT2A 223/4885HDAC1 2/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.