Sugi Predict

Sugi Predict / Compounds / SCHEMBL15480452

SCHEMBL15480452

SCHEMBL15480452

O=C(O)CCCCCCC(=O)Nc1ccncc1

nearest known ligand 0.77

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ BCHE P06276 1/20 0.77
▸ HDAC4 P56524 10/20 0.76
▸ HDAC1 Q13547 10/20 0.76
▸ HDAC11 Q96DB2 10/20 0.76
▸ HDAC8 Q9BY41 10/20 0.76
▸ HDAC6 Q9UBN7 10/20 0.76
▸ HDAC5 Q9UQL6 10/20 0.76
▸ HDAC7 Q8WUI4 9/20 0.76
▸ HDAC9 Q9UKV0 9/20 0.76
▸ HDAC3 O15379 9/20 0.76
▸ HDAC2 Q92769 9/20 0.76
▸ HDAC10 Q969S8 9/20 0.76
▸ TSHR P16473 1/20 0.61
▸ MAPK1 P28482 1/20 0.61
▸ L3MBTL1 Q9Y468 1/20 0.61
▸ LMNA P02545 2/20 0.59
▸ ALDH1A1 P00352 3/20 0.58
▸ POLB P06746 1/20 0.58
▸ HPGD P15428 2/20 0.56
▸ KDM4E B2RXH2 1/20 0.56

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16353862 0.95 BCHE (0.80) BCHEHDAC4HDAC1HDAC11HDAC8
SCHEMBL16353729 0.87 BCHE (1.00) BCHEHDAC4HDAC1HDAC11HDAC8
SCHEMBL8082656 0.86 HDAC1 (1.00) BCHEHDAC4HDAC1HDAC11HDAC8
SCHEMBL16596254 0.85 HPGD (0.76) BCHEHDAC4HDAC1HDAC11HDAC8
SCHEMBL14428854 0.85 HDAC4 (0.73) BCHEHDAC4HDAC1HDAC11HDAC8
SCHEMBL10581544 0.85 HPGD (0.76) BCHEHDAC4HDAC1HDAC11HDAC8
SCHEMBL8671160 0.85 HPGD (0.76) BCHEHDAC4HDAC1HDAC11HDAC8
SCHEMBL30444817 0.85 HDAC1 (0.73) BCHEHDAC4HDAC1HDAC11HDAC8
SCHEMBL28347915 0.85 HPGD (0.76) BCHEHDAC4HDAC1HDAC11HDAC8
SCHEMBL1064861 0.84 HDAC4 (0.77) HDAC4HDAC1HDAC11HDAC8HDAC6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20210060014-A1 COMPOUNDS AND METHODS FOR IMPROVING IMPAIRED ENDOGENOUS FIBRINOLYSIS USING HISTONE DEACETYLASE INHIBITORS CERENO SCIENTIFIC AB (SE) 2021-03-04 — — US disclosed
US-20170020874-A1 COMPOUNDS AND METHODS FOR IMPROVING IMPAIRED ENDOGENOUS FIBRINOLYSIS USING HISTONE DEACETYLASE INHIBITORS CERENO SCIENT AB (SE) 2017-01-26 — — US disclosed
US-20140051716-A1 COMPOUNDS AND METHODS FOR IMPROVING IMPAIRED ENDOGENOUS FIBRINOLYSIS USING HISTONE DEACETYLASE INHIBITORS CERENO SCIENTIFIC AB 2014-02-20 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20140051716-A1 COMPOUNDS AND METHODS FOR IMPROVING IMPAIRED ENDOGENOUS FIBRINOLYSIS USING HISTONE DEACETYLASE INHIBITORS HDAC3, HDAC1, HDAC2 BCHE 1660/4885HDAC4 7/4885HDAC1 2/4885
US-20170020874-A1 COMPOUNDS AND METHODS FOR IMPROVING IMPAIRED ENDOGENOUS FIBRINOLYSIS USING HISTONE DEACETYLASE INHIBITORS HDAC3, HDAC1, HDAC2 BCHE 1660/4885HDAC4 7/4885HDAC1 2/4885
US-20210060014-A1 COMPOUNDS AND METHODS FOR IMPROVING IMPAIRED ENDOGENOUS FIBRINOLYSIS USING HISTONE DEACETYLASE INHIBITORS HDAC3, HDAC1, HDAC2 BCHE 1660/4885HDAC4 7/4885HDAC1 2/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.