Sugi Predict

Sugi Predict / Compounds / SCHEMBL15480587

SCHEMBL15480587

SCHEMBL15480587

O=C(NO)c1ccc(NS(=O)(=O)Cc2ccccc2)cc1

nearest known ligand 0.71

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ HPGD P15428 2/20 0.71
▸ HDAC1 Q13547 8/20 0.63
▸ KMT2A Q03164 1/20 0.60
▸ PGR P06401 1/20 0.57
▸ ALOX15 P16050 2/20 0.57
▸ HSD17B10 Q99714 2/20 0.57
▸ AR P10275 1/20 0.56
▸ HDAC8 Q9BY41 7/20 0.54
▸ HDAC6 Q9UBN7 6/20 0.54
▸ HDAC2 Q92769 5/20 0.54
▸ CA1 P00915 2/20 0.53
▸ CA2 P00918 1/20 0.53
▸ MMP1 P03956 1/20 0.53
▸ MMP2 P08253 1/20 0.53
▸ MMP9 P14780 1/20 0.53
▸ MMP8 P22894 1/20 0.53
▸ MMP13 P45452 1/20 0.53
▸ BRPF1 P55201 1/20 0.52
▸ LMNA P02545 1/20 0.51
▸ HDAC3 O15379 2/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31122757 0.88 HDAC1 (0.72) HPGDHDAC1KMT2AHDAC8HDAC6
SCHEMBL8429744 0.87 HPGD (0.74) HPGDHDAC1KMT2APGRALOX15
SCHEMBL1650346 0.86 HPGD (0.77) HPGDHDAC1KMT2APGRALOX15
SCHEMBL5943744 0.84 PARP1 (0.54) HPGDHDAC1HDAC8HDAC6HDAC2
SCHEMBL7211680 0.83 HPGD (0.73) HPGDHDAC1KMT2APGRALOX15
SCHEMBL8241515 0.83 HPGD (0.68) HPGDHDAC1KMT2APGRALOX15
SCHEMBL13545205 0.81 HPGD (0.74) HPGDHDAC1KMT2APGRALOX15
SCHEMBL14812282 0.81 HDAC1 (0.68) HPGDHDAC1KMT2APGRALOX15
SCHEMBL3560317 0.81 HPGD (0.69) HPGDHDAC1KMT2APGRALOX15
SCHEMBL633995 0.80 KMT2A (0.76) HPGDHDAC1KMT2APGRALOX15

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20210060014-A1 COMPOUNDS AND METHODS FOR IMPROVING IMPAIRED ENDOGENOUS FIBRINOLYSIS USING HISTONE DEACETYLASE INHIBITORS CERENO SCIENTIFIC AB (SE) 2021-03-04 — — US disclosed
US-20170020874-A1 COMPOUNDS AND METHODS FOR IMPROVING IMPAIRED ENDOGENOUS FIBRINOLYSIS USING HISTONE DEACETYLASE INHIBITORS CERENO SCIENT AB (SE) 2017-01-26 — — US disclosed
US-20140051716-A1 COMPOUNDS AND METHODS FOR IMPROVING IMPAIRED ENDOGENOUS FIBRINOLYSIS USING HISTONE DEACETYLASE INHIBITORS CERENO SCIENTIFIC AB 2014-02-20 — — US disclosed
US-20140051716-A1 COMPOUNDS AND METHODS FOR IMPROVING IMPAIRED ENDOGENOUS FIBRINOLYSIS USING HISTONE DEACETYLASE INHIBITORS CERENO SCIENTIFIC AB 2014-02-20 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20140051716-A1 COMPOUNDS AND METHODS FOR IMPROVING IMPAIRED ENDOGENOUS FIBRINOLYSIS USING HISTONE DEACETYLASE INHIBITORS HDAC3, HDAC1, HDAC2 HPGD 1305/4885HDAC1 2/4885KMT2A 223/4885
US-20170020874-A1 COMPOUNDS AND METHODS FOR IMPROVING IMPAIRED ENDOGENOUS FIBRINOLYSIS USING HISTONE DEACETYLASE INHIBITORS HDAC3, HDAC1, HDAC2 HPGD 1305/4885HDAC1 2/4885KMT2A 223/4885
US-20210060014-A1 COMPOUNDS AND METHODS FOR IMPROVING IMPAIRED ENDOGENOUS FIBRINOLYSIS USING HISTONE DEACETYLASE INHIBITORS HDAC3, HDAC1, HDAC2 HPGD 1305/4885HDAC1 2/4885KMT2A 223/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.