Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 2/20 | 0.73 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.62 |
| ▸ | PGR | P06401 | 1/20 | 0.59 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.58 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.58 |
| ▸ | AR | P10275 | 1/20 | 0.57 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.57 |
| ▸ | LMNA | P02545 | 2/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | BRD4 | O60885 | 1/20 | 0.51 |
| ▸ | CA1 | P00915 | 1/20 | 0.50 |
| ▸ | CA2 | P00918 | 1/20 | 0.50 |
| ▸ | MMP1 | P03956 | 1/20 | 0.50 |
| ▸ | MMP2 | P08253 | 1/20 | 0.50 |
| ▸ | MMP9 | P14780 | 1/20 | 0.50 |
| ▸ | MMP8 | P22894 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1650346 | 0.87 | HPGD (0.77) | HPGDKMT2APGRALOX15HSD17B10 | |
| SCHEMBL15480587 | 0.83 | HPGD (0.71) | HPGDKMT2APGRALOX15HSD17B10 | |
| SCHEMBL8429744 | 0.82 | HPGD (0.74) | HPGDKMT2APGRALOX15HSD17B10 | |
| SCHEMBL13545205 | 0.82 | HPGD (0.74) | HPGDKMT2APGRALOX15HSD17B10 | |
| SCHEMBL3560317 | 0.82 | HPGD (0.69) | HPGDKMT2APGRALOX15HSD17B10 | |
| SCHEMBL633995 | 0.81 | KMT2A (0.76) | HPGDKMT2APGRALOX15HSD17B10 | |
| SCHEMBL13543300 | 0.81 | HPGD (0.72) | HPGDKMT2APGRALOX15HSD17B10 | |
| SCHEMBL6567551 | 0.80 | KMT2A (0.70) | HPGDKMT2APGRALOX15HSD17B10 | |
| SCHEMBL1422100 | 0.79 | HPGD (0.66) | HPGDKMT2APGRALOX15HSD17B10 | |
| SCHEMBL8241515 | 0.79 | HPGD (0.68) | HPGDKMT2APGRALOX15HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0988302-B1 | BENZONAPHTHYRIDINES | ALTANA PHARMA AG (DE) | 2003-02-19 | — | — | EP | disclosed |
| US-6384047-B1 | BREATHING DISORDERS AND HYPOTENSIVE AGENTS | BYK GULDEN LOMBERG CHEMISCHE FABRIK GMBH (DE) | 2002-05-07 | — | — | US | disclosed |
| US-6127378-A | A PHOSPHODIESTERASE ENZYME INHIBITOR AS BRONCHIAL THERAPEUTICS, AN ANTIINFLAMMATORY AGENT TREATING ASTHMA PROPHYLAXIS, SKIN DISORDERS, INTESTINE DISORDERS, EYE DISORDERS, CENTRAL NERVOUS SYSTEM DISORDERS, JOINTS DISORDERS | BYK GULDEN LOMBERG CHEMISCHE FABRIK GMBH (DE) | 2000-10-03 | — | — | US | disclosed |
| EP-0988302-A1 | BENZONAPHTHYRIDINES | Byk Gulden Lomberg Chemische Fabrik GmbH (DE) | 2000-03-29 | — | — | EP | disclosed |
| WO-1998055481-A1 | BENZONAPHTHYRIDINE | BYK GULDEN LOMBERG CHEMISCHE FABRIK GMBH (DE) | 1998-12-10 | — | — | WO | disclosed |
| EP-0106175-B1 | ELECTRICALLY CONDUCTIVE LIQUID CRYSTALLINE SUBSTANCE AND POLYMER | SHOWA DENKO KABUSHIKI KAISHA (JP) | 1988-12-07 | — | — | EP | disclosed |
| EP-0067885-B1 | HETEROCYCLIC 5-MEMBERED RING COMPOUNDS | SANTEN PHARMACEUTICAL CO., LTD. (JP) | 1985-09-04 | — | — | EP | disclosed |
| US-4464371-A | HYPOTENSIVE AGENTS | SANTEN PHARMACEUTICAL CO., LTD. (JP) | 1984-08-07 | — | — | US | disclosed |
| EP-0067885-A1 | HETEROCYCLIC 5-MEMBERED RING COMPOUNDS | SANTEN PHARMACEUTICAL CO., LTD. (JP) | 1982-12-29 | — | — | EP | disclosed |