Sugi Predict

Sugi Predict / Compounds / SCHEMBL15480652

SCHEMBL15480652

SCHEMBL15480652

CN(C(=O)c1ccc(C(=O)O)cc1)c1ccc(C(=O)NO)cc1

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ HDAC6 Q9UBN7 12/20 0.56
▸ HDAC1 Q13547 8/20 0.56
▸ HDAC8 Q9BY41 7/20 0.51
▸ HTT P42858 1/20 0.50
▸ NR1H4 Q96RI1 1/20 0.48
▸ HDAC2 Q92769 2/20 0.47
▸ NR1H3 Q13133 2/20 0.47
▸ NR1H2 P55055 1/20 0.47
▸ EGFR P00533 1/20 0.47
▸ ERBB2 P04626 1/20 0.47
▸ KMT2A Q03164 2/20 0.46
▸ KDM4E B2RXH2 1/20 0.46
▸ HDAC3 O15379 2/20 0.46
▸ HDAC7 Q8WUI4 2/20 0.46
▸ CA12 O43570 1/20 0.46
▸ CA1 P00915 1/20 0.46
▸ IDO1 P14902 1/20 0.46
▸ ALOX15 P16050 1/20 0.46
▸ CA9 Q16790 1/20 0.46
▸ HSD17B10 Q99714 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4610487 0.90 HDAC1 (0.61) HDAC6HDAC1HDAC8HTTHDAC2
SCHEMBL15480654 0.88 HDAC6 (0.72) HDAC6HDAC1HDAC8HDAC2HDAC3
SCHEMBL9094961 0.88 KMT2A (0.56) HTTNR1H4NR1H3NR1H2EGFR
SCHEMBL4659080 0.87 HDAC6 (0.67) HDAC6HDAC1HDAC8HTTHDAC2
SCHEMBL4659287 0.87 HDAC6 (0.67) HDAC6HDAC1HDAC8HTTHDAC2
SCHEMBL4654851 0.84 HDAC1 (0.69) HDAC6HDAC1HDAC8NR1H4HDAC3
SCHEMBL4657405 0.84 HDAC1 (0.69) HDAC6HDAC1HDAC8NR1H4HDAC3
SCHEMBL24891812 0.83 EGFR (0.49) HTTNR1H4NR1H3NR1H2EGFR
SCHEMBL4654830 0.83 HDAC6 (0.59) HDAC6HDAC1HDAC8NR1H4HDAC2
SCHEMBL15480658 0.83 CA1 (0.70) HDAC6HDAC1HDAC8HTTHDAC2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20210060014-A1 COMPOUNDS AND METHODS FOR IMPROVING IMPAIRED ENDOGENOUS FIBRINOLYSIS USING HISTONE DEACETYLASE INHIBITORS CERENO SCIENTIFIC AB (SE) 2021-03-04 — — US disclosed
US-20170020874-A1 COMPOUNDS AND METHODS FOR IMPROVING IMPAIRED ENDOGENOUS FIBRINOLYSIS USING HISTONE DEACETYLASE INHIBITORS CERENO SCIENT AB (SE) 2017-01-26 — — US disclosed
US-20140051716-A1 COMPOUNDS AND METHODS FOR IMPROVING IMPAIRED ENDOGENOUS FIBRINOLYSIS USING HISTONE DEACETYLASE INHIBITORS CERENO SCIENTIFIC AB 2014-02-20 — — US disclosed
US-20140051716-A1 COMPOUNDS AND METHODS FOR IMPROVING IMPAIRED ENDOGENOUS FIBRINOLYSIS USING HISTONE DEACETYLASE INHIBITORS CERENO SCIENTIFIC AB 2014-02-20 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20140051716-A1 COMPOUNDS AND METHODS FOR IMPROVING IMPAIRED ENDOGENOUS FIBRINOLYSIS USING HISTONE DEACETYLASE INHIBITORS HDAC3, HDAC1, HDAC2 HDAC6 10/4885HDAC1 2/4885HDAC8 4/4885
US-20170020874-A1 COMPOUNDS AND METHODS FOR IMPROVING IMPAIRED ENDOGENOUS FIBRINOLYSIS USING HISTONE DEACETYLASE INHIBITORS HDAC3, HDAC1, HDAC2 HDAC6 10/4885HDAC1 2/4885HDAC8 4/4885
US-20210060014-A1 COMPOUNDS AND METHODS FOR IMPROVING IMPAIRED ENDOGENOUS FIBRINOLYSIS USING HISTONE DEACETYLASE INHIBITORS HDAC3, HDAC1, HDAC2 HDAC6 10/4885HDAC1 2/4885HDAC8 4/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.