Sugi Predict

Sugi Predict / Compounds / SCHEMBL15480658

SCHEMBL15480658

SCHEMBL15480658

COc1ccc(C(=O)N(C)c2ccc(C(=O)NO)cc2)cc1

nearest known ligand 0.70

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ CA1 P00915 2/20 0.70
▸ CA2 P00918 2/20 0.70
▸ KMT2A Q03164 1/20 0.56
▸ HSD17B1 P14061 1/20 0.55
▸ HSD17B2 P37059 1/20 0.55
▸ MCHR1 Q99705 2/20 0.53
▸ SMN1; SMN2 Q16637 2/20 0.53
▸ NPC1 O15118 1/20 0.53
▸ TP53 P04637 1/20 0.53
▸ ALOX15 P16050 1/20 0.53
▸ RAB9A P51151 1/20 0.53
▸ PLK1 P53350 1/20 0.51
▸ HDAC1 Q13547 5/20 0.51
▸ HDAC6 Q9UBN7 5/20 0.51
▸ HDAC8 Q9BY41 3/20 0.51
▸ MAPT P10636 2/20 0.50
▸ LMNA P02545 1/20 0.50
▸ CYP1A2 P05177 1/20 0.50
▸ ALDH1A1 P00352 2/20 0.49
▸ HTT P42858 2/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6806574 0.89 HSD17B1 (0.65) CA1CA2KMT2AHSD17B1HSD17B2
SCHEMBL15480654 0.84 HDAC6 (0.72) HDAC1HDAC6HDAC8MAPTALDH1A1
SCHEMBL942259 0.83 CA1 (1.00) CA1CA2KMT2ASMN1; SMN2NPC1
SCHEMBL15480652 0.83 HDAC6 (0.56) CA1KMT2ANPC1ALOX15RAB9A
SCHEMBL4659080 0.83 HDAC6 (0.67) HSD17B1HSD17B2SMN1; SMN2NPC1RAB9A
SCHEMBL4659287 0.83 HDAC6 (0.67) HSD17B1HSD17B2SMN1; SMN2NPC1RAB9A
SCHEMBL4090142 0.83 HSD17B1 (0.58) CA1CA2KMT2AHSD17B1HSD17B2
SCHEMBL4610487 0.83 HDAC1 (0.61) CA1KMT2ANPC1ALOX15RAB9A
SCHEMBL5582735 0.83 CA1 (0.67) CA1CA2KMT2AHSD17B1HSD17B2
Hydrochloric Acid SCHEMBL8880498 0.82 CA1 (0.96) CA1CA2KMT2ASMN1; SMN2NPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20210060014-A1 COMPOUNDS AND METHODS FOR IMPROVING IMPAIRED ENDOGENOUS FIBRINOLYSIS USING HISTONE DEACETYLASE INHIBITORS CERENO SCIENTIFIC AB (SE) 2021-03-04 — — US disclosed
US-20170020874-A1 COMPOUNDS AND METHODS FOR IMPROVING IMPAIRED ENDOGENOUS FIBRINOLYSIS USING HISTONE DEACETYLASE INHIBITORS CERENO SCIENT AB (SE) 2017-01-26 — — US disclosed
US-20140051716-A1 COMPOUNDS AND METHODS FOR IMPROVING IMPAIRED ENDOGENOUS FIBRINOLYSIS USING HISTONE DEACETYLASE INHIBITORS CERENO SCIENTIFIC AB 2014-02-20 — — US disclosed
US-20140051716-A1 COMPOUNDS AND METHODS FOR IMPROVING IMPAIRED ENDOGENOUS FIBRINOLYSIS USING HISTONE DEACETYLASE INHIBITORS CERENO SCIENTIFIC AB 2014-02-20 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20140051716-A1 COMPOUNDS AND METHODS FOR IMPROVING IMPAIRED ENDOGENOUS FIBRINOLYSIS USING HISTONE DEACETYLASE INHIBITORS HDAC3, HDAC1, HDAC2 CA1 490/4885CA2 675/4885KMT2A 223/4885
US-20170020874-A1 COMPOUNDS AND METHODS FOR IMPROVING IMPAIRED ENDOGENOUS FIBRINOLYSIS USING HISTONE DEACETYLASE INHIBITORS HDAC3, HDAC1, HDAC2 CA1 490/4885CA2 675/4885KMT2A 223/4885
US-20210060014-A1 COMPOUNDS AND METHODS FOR IMPROVING IMPAIRED ENDOGENOUS FIBRINOLYSIS USING HISTONE DEACETYLASE INHIBITORS HDAC3, HDAC1, HDAC2 CA1 490/4885CA2 675/4885KMT2A 223/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.