Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC7A11 | Q9UPY5 | 3/20 | 0.70 |
| ▸ | BRD4 | O60885 | 7/20 | 0.56 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | BRD3 | Q15059 | 1/20 | 0.51 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.51 |
| ▸ | BRD7 | Q9NPI1 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | LMNA | P02545 | 3/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | ABCC3 | O15438 | 1/20 | 0.50 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.50 |
| ▸ | USP2 | O75604 | 1/20 | 0.50 |
| ▸ | SLCO2B1 | O94956 | 1/20 | 0.50 |
| ▸ | CA1 | P00915 | 1/20 | 0.50 |
| ▸ | CA2 | P00918 | 1/20 | 0.50 |
| ▸ | MMP1 | P03956 | 1/20 | 0.50 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15499066 | 0.84 | SLC7A11 (0.58) | SLC7A11BRD4POLBBRD3CREBBP | |
| SCHEMBL15499078 | 0.83 | KDM4E (0.57) | BRD4POLBBRD3CREBBPBRD7 | |
| SCHEMBL8067761 | 0.82 | SLC7A11 (1.00) | SLC7A11BRD4POLBKDM4EALDH1A1 | |
| SCHEMBL8068359 | 0.82 | SLC7A11 (1.00) | SLC7A11BRD4POLBKDM4EALDH1A1 | |
| SCHEMBL8069397 | 0.82 | SLC7A11 (0.79) | SLC7A11BRD4POLBBRD3CREBBP | |
| SCHEMBL8069398 | 0.82 | SLC7A11 (0.79) | SLC7A11BRD4POLBBRD3CREBBP | |
| SCHEMBL15496562 | 0.81 | BRD4 (0.71) | SLC7A11BRD4POLBBRD3CREBBP | |
| SCHEMBL15496600 | 0.79 | SLC7A11 (0.62) | SLC7A11BRD4POLBBRD3CREBBP | |
| SCHEMBL8072369 | 0.78 | SLC7A11 (0.69) | SLC7A11BRD4POLBBRD3CREBBP | |
| SCHEMBL8072366 | 0.78 | SLC7A11 (0.69) | SLC7A11BRD4POLBBRD3CREBBP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140066410-A1 | INHIBITORS OF BROMODOMAINS AS MODULATORS OF GENE EXPRESSION | ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI (US) | 2014-03-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140066410-A1 | INHIBITORS OF BROMODOMAINS AS MODULATORS OF GENE EXPRESSION | NFKBIA, NFKB2, IKBKG | SLC7A11 4544/4885BRD4 23/4885POLB 96/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.