Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C9 | P11712 | 4/20 | 0.71 |
| ▸ | ADORA3 | P0DMS8 | 4/20 | 0.71 |
| ▸ | LMNA | P02545 | 3/20 | 0.71 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.71 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.71 |
| ▸ | HTT | P42858 | 2/20 | 0.71 |
| ▸ | NR1I2 | O75469 | 2/20 | 0.71 |
| ▸ | PGR | P06401 | 2/20 | 0.71 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.71 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.71 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.71 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.71 |
| ▸ | DRD3 | P35462 | 1/20 | 0.71 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.71 |
| ▸ | GAA | P10253 | 2/20 | 0.47 |
| ▸ | MGAM | O43451 | 1/20 | 0.47 |
| ▸ | AMY1A | P0DUB6 | 1/20 | 0.47 |
| ▸ | SI | P14410 | 1/20 | 0.47 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19882221 | 0.89 | ADORA3 (0.74) | CYP2C9ADORA3LMNACYP3A4CYP2C19 | |
| SCHEMBL9680023 | 0.83 | ADORA3 (0.74) | CYP2C9ADORA3LMNACYP3A4CYP2C19 | |
| SCHEMBL9872301 | 0.83 | CYP2C9 (0.81) | CYP2C9ADORA3LMNACYP3A4CYP2C19 | |
| SCHEMBL9680033 | 0.83 | ADORA3 (0.74) | CYP2C9ADORA3LMNACYP3A4CYP2C19 | |
| Lacidipine SCHEMBL29352892 | 0.83 | CYP2C9 (1.00) | CYP2C9ADORA3LMNACYP3A4CYP2C19 | |
| Lacidipine SCHEMBL49278 | 0.83 | CYP2C9 (1.00) | CYP2C9ADORA3LMNACYP3A4CYP2C19 | |
| Lacidipine SCHEMBL49277 | 0.83 | CYP2C9 (1.00) | CYP2C9ADORA3LMNACYP3A4CYP2C19 | |
| Lacidipine SCHEMBL28158205 | 0.81 | CYP2C9 (0.96) | CYP2C9ADORA3LMNACYP3A4CYP2C19 | |
| SCHEMBL28505406 | 0.80 | ADORA3 (0.70) | CYP2C9ADORA3LMNACYP3A4CYP2C19 | |
| SCHEMBL29261988 | 0.80 | ADORA3 (0.92) | CYP2C9ADORA3LMNACYP3A4CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2705839-A1 | Pharmaceutical composition comprising lacidipine and process of preparation | Rivopharm SA (CH) | 2014-03-12 | — | — | EP | disclosed |