Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 11/20 | 0.56 |
| ▸ | HTR1F | P30939 | 4/20 | 0.37 |
| ▸ | CCR3 | P51677 | 2/20 | 0.36 |
| ▸ | TNKS | O95271 | 1/20 | 0.35 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1098658 | 0.90 | P2RX7 (0.59) | P2RX7HTR1FCCR3 | |
| SCHEMBL1100528 | 0.81 | P2RX7 (0.66) | P2RX7HTR1FHPGD | |
| SCHEMBL1099947 | 0.80 | P2RX7 (0.67) | P2RX7 | |
| SCHEMBL1099744 | 0.80 | P2RX7 (0.65) | P2RX7HTR1FALDH1A1HPGD | |
| SCHEMBL1100367 | 0.80 | P2RX7 (0.65) | P2RX7HTR1FALDH1A1HPGD | |
| SCHEMBL1099198 | 0.80 | P2RX7 (0.65) | P2RX7HTR1FALDH1A1HPGD | |
| SCHEMBL1108383 | 0.80 | P2RX7 (0.70) | P2RX7 | |
| SCHEMBL1100598 | 0.79 | P2RX7 (0.62) | P2RX7ALDH1A1HPGD | |
| SCHEMBL1100296 | 0.79 | P2RX7 (0.65) | P2RX7HTR1FHPGD | |
| SCHEMBL1098514 | 0.78 | P2RX7 (0.76) | P2RX7ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2393781-B1 | DIHYDROPYRIDONE UREAS AS P2X7 MODULATORS | HOFFMANN LA ROCHE (CH) | 2014-03-12 | — | — | EP | disclosed |