Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 13/20 | 0.71 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | RBP4 | P02753 | 1/20 | 0.34 |
| ▸ | HTR2A | P28223 | 2/20 | 0.33 |
| ▸ | HTR2C | P28335 | 2/20 | 0.33 |
| ▸ | HTR2B | P41595 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1099424 | 0.93 | P2RX7 (0.83) | P2RX7HTR2AHTR2CHTR2B | |
| SCHEMBL1099236 | 0.83 | P2RX7 (1.00) | P2RX7KMT2APOLB | |
| SCHEMBL1099960 | 0.83 | P2RX7 (0.88) | P2RX7 | |
| SCHEMBL1100203 | 0.83 | P2RX7 (1.00) | P2RX7 | |
| SCHEMBL1100166 | 0.81 | P2RX7 (1.00) | P2RX7MEN1KMT2A | |
| SCHEMBL1099956 | 0.80 | P2RX7 (0.74) | P2RX7MAPTLMNANPSR1 | |
| SCHEMBL1099212 | 0.80 | P2RX7 (0.74) | P2RX7MAPTLMNANPSR1 | |
| SCHEMBL1099254 | 0.80 | P2RX7 (0.86) | P2RX7 | |
| SCHEMBL1100350 | 0.80 | P2RX7 (0.74) | P2RX7MAPTLMNANPSR1 | |
| SCHEMBL1099251 | 0.80 | P2RX7 (0.86) | P2RX7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2393781-B1 | DIHYDROPYRIDONE UREAS AS P2X7 MODULATORS | HOFFMANN LA ROCHE (CH) | 2014-03-12 | — | — | EP | disclosed |