Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 13/20 | 0.71 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1101409 | 0.92 | P2RX7 (0.80) | P2RX7SMN1; SMN2HSD17B10TRPV1KMT2A | |
| SCHEMBL1100253 | 0.84 | P2RX7 (0.79) | P2RX7SMN1; SMN2HSD17B10TRPV1 | |
| SCHEMBL1099750 | 0.84 | P2RX7 (1.00) | P2RX7SMN1; SMN2 | |
| SCHEMBL1099236 | 0.83 | P2RX7 (1.00) | P2RX7SMN1; SMN2HSD17B10TRPV1KMT2A | |
| SCHEMBL1100118 | 0.81 | P2RX7 (0.78) | P2RX7SMN1; SMN2HSD17B10TRPV1KMT2A | |
| SCHEMBL1100095 | 0.81 | P2RX7 (0.84) | P2RX7SMN1; SMN2HSD17B10 | |
| SCHEMBL1098654 | 0.81 | P2RX7 (0.84) | P2RX7SMN1; SMN2HSD17B10 | |
| SCHEMBL1098514 | 0.80 | P2RX7 (0.76) | P2RX7HSD17B10TRPV1 | |
| SCHEMBL1098788 | 0.80 | P2RX7 (0.84) | P2RX7SMN1; SMN2KMT2A | |
| SCHEMBL1100057 | 0.80 | P2RX7 (0.84) | P2RX7SMN1; SMN2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2393781-B1 | DIHYDROPYRIDONE UREAS AS P2X7 MODULATORS | HOFFMANN LA ROCHE (CH) | 2014-03-12 | — | — | EP | disclosed |