Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 2/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.51 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.51 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.51 |
| ▸ | DPP4 | P27487 | 2/20 | 0.31 |
| ▸ | JAK2 | O60674 | 1/20 | 0.31 |
| ▸ | JAK3 | P52333 | 1/20 | 0.31 |
| ▸ | TNF | P01375 | 3/20 | 0.30 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.30 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.30 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.30 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.30 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.30 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17954534 | 0.89 | CYP3A4 (0.62) | CYP3A4CYP2C9CYP1A2CYP2C8CYP2D6 | |
| SCHEMBL1550502 | 0.88 | CYP3A4 (0.54) | CYP3A4CYP2C9CYP1A2CYP2C8CYP2D6 | |
| SCHEMBL2629201 | 0.85 | CYP3A4 (0.51) | CYP3A4CYP2C9CYP1A2CYP2C8CYP2D6 | |
| SCHEMBL1550813 | 0.85 | CYP3A4 (0.49) | CYP3A4CYP2C9CYP1A2CYP2C8CYP2D6 | |
| SCHEMBL2629214 | 0.83 | CYP3A4 (0.50) | CYP3A4CYP2C9CYP1A2CYP2C8CYP2D6 | |
| SCHEMBL2629202 | 0.82 | CYP3A4 (0.54) | CYP3A4CYP2C9CYP1A2CYP2C8CYP2D6 | |
| SCHEMBL2629197 | 0.80 | CYP3A4 (0.65) | CYP3A4CYP2C9CYP1A2CYP2C8CYP2D6 | |
| SCHEMBL2629213 | 0.80 | CYP3A4 (0.53) | CYP3A4CYP2C9CYP1A2CYP2C8CYP2D6 | |
| SCHEMBL22783647 | 0.79 | CYP3A4 (0.53) | CYP3A4CYP2C9CYP1A2CYP2C8CYP2D6 | |
| SCHEMBL3231262 | 0.77 | CYP2C9 (0.53) | CYP3A4CYP2C9CYP1A2CYP2C8CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8242124-B2 | Diketopiperidine derivatives as HIV attachment inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2012-08-14 | — | — | US | disclosed |
| US-8242124-B2 | Diketopiperidine derivatives as HIV attachment inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2012-08-14 | — | — | US | disclosed |
| US-8242124-B2 | Diketopiperidine derivatives as HIV attachment inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2012-08-14 | — | — | US | disclosed |
| EP-2313408-B1 | DIKETOPIPERIDINE DERIVATIVES AS HIV ATTACHMENT INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2012-07-11 | — | — | EP | disclosed |
| EP-2313408-B1 | DIKETOPIPERIDINE DERIVATIVES AS HIV ATTACHMENT INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2012-07-11 | — | — | EP | disclosed |
| EP-2313408-A1 | DIKETOPIPERIDINE DERIVATIVES AS HIV ATTACHMENT INHIBITORS | Bristol-Myers Squibb Company (US) | 2011-04-27 | — | — | EP | disclosed |
| US-20090325985-A1 | Diketopiperidine Derivatives as HIV Attachment Inhibitors | BRISTOL-MYERS SQUIBB COMPANY | 2009-12-31 | — | — | US | disclosed |
| US-20090325985-A1 | Diketopiperidine Derivatives as HIV Attachment Inhibitors | BRISTOL-MYERS SQUIBB COMPANY | 2009-12-31 | — | — | US | disclosed |
| US-20090325985-A1 | Diketopiperidine Derivatives as HIV Attachment Inhibitors | BRISTOL-MYERS SQUIBB COMPANY | 2009-12-31 | — | — | US | disclosed |
| WO-2009158396-A1 | DIKETOPIPERIDINE DERIVATIVES AS HIV ATTACHMENT INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2009-12-30 | — | — | WO | disclosed |
| WO-2009158396-A1 | DIKETOPIPERIDINE DERIVATIVES AS HIV ATTACHMENT INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2009-12-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090325985-A1 | Diketopiperidine Derivatives as HIV Attachment Inhibitors | SAMHD1, CD4, DNPEP | CYP3A4 962/4885CYP2C9 2999/4885CYP1A2 2784/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.