Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAF1 | P04049 | 7/20 | 0.59 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.59 |
| ▸ | BRAF | P15056 | 7/20 | 0.57 |
| ▸ | KDR | P35968 | 5/20 | 0.57 |
| ▸ | RET | P07949 | 3/20 | 0.55 |
| ▸ | PLK4 | O00444 | 2/20 | 0.55 |
| ▸ | AURKA | O14965 | 2/20 | 0.55 |
| ▸ | MAPK13 | O15264 | 2/20 | 0.55 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.55 |
| ▸ | ABL1 | P00519 | 2/20 | 0.55 |
| ▸ | LCK | P06239 | 2/20 | 0.55 |
| ▸ | FYN | P06241 | 2/20 | 0.55 |
| ▸ | LYN | P07948 | 2/20 | 0.55 |
| ▸ | SRC | P12931 | 2/20 | 0.55 |
| ▸ | RPS6KB1 | P23443 | 2/20 | 0.55 |
| ▸ | EPHA2 | P29317 | 2/20 | 0.55 |
| ▸ | AXL | P30530 | 2/20 | 0.55 |
| ▸ | FRK | P42685 | 2/20 | 0.55 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.55 |
| ▸ | BLK | P51451 | 2/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14422934 | 0.91 | RAF1 (0.72) | RAF1EPHX2BRAFKDRRET | |
| SCHEMBL14422927 | 0.87 | RAF1 (0.65) | RAF1EPHX2BRAFKDRRET | |
| SCHEMBL14422926 | 0.80 | KDR (0.71) | RAF1EPHX2BRAFKDRRET | |
| SCHEMBL14422929 | 0.79 | KDR (0.85) | RAF1EPHX2BRAFKDRRET | |
| SCHEMBL14422924 | 0.77 | KDR (0.75) | RAF1EPHX2BRAFKDRRET | |
| SCHEMBL14022017 | 0.76 | BRAF (0.72) | RAF1EPHX2BRAFKDRMAPK14 | |
| SCHEMBL14422932 | 0.75 | KDR (0.70) | RAF1EPHX2BRAFKDRRET | |
| SCHEMBL5635415 | 0.75 | RET (0.86) | RAF1EPHX2BRAFKDRRET | |
| SCHEMBL15624828 | 0.74 | RAF1 (1.00) | RAF1EPHX2BRAFKDRRET | |
| SCHEMBL2748558 | 0.74 | KDR (0.56) | BRAFKDRRETPDGFRBKIT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1641759-B1 | MALONAMIDE DERIVATIVES | MERCK PATENT GMBH (DE) | 2014-03-12 | — | — | EP | disclosed |