Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 20/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.46 |
| ▸ | CTSD | P07339 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15509891 | 1.00 | BACE1 (0.46) | BACE1KCNH2CTSD | |
| SCHEMBL1994871 | 0.85 | BACE1 (0.48) | BACE1KCNH2CTSD | |
| SCHEMBL1994874 | 0.85 | BACE1 (0.48) | BACE1KCNH2CTSD | |
| SCHEMBL6845317 | 0.83 | BACE1 (0.69) | BACE1KCNH2CTSD | |
| SCHEMBL13401364 | 0.81 | BACE1 (0.50) | BACE1KCNH2CTSD | |
| SCHEMBL1994275 | 0.80 | BACE1 (0.49) | BACE1CTSD | |
| SCHEMBL1998989 | 0.80 | BACE1 (0.49) | BACE1CTSD | |
| SCHEMBL1994274 | 0.80 | BACE1 (0.49) | BACE1CTSD | |
| SCHEMBL15510367 | 0.80 | BACE1 (0.62) | BACE1KCNH2CTSD | |
| SCHEMBL13383464 | 0.79 | BACE1 (0.54) | BACE1CTSD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2328903-B1 | SPIRO-TETRACYCLIC RING COMPOUNDS AS BETASECRETASE MODULATORS AND METHODS OF USE | AMGEN INC (US) | 2014-03-05 | — | — | EP | disclosed |