⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL3795135 | 0.98 | ACHE (0.33) | — | |
| SCHEMBL23210447 | 0.83 | JAK2 (0.36) | — | |
| SCHEMBL574538 | 0.82 | — | — | |
| Hydrochloric Acid SCHEMBL15875416 | 0.80 | ACHE (0.43) | — | |
| SCHEMBL15651247 | 0.79 | JAK2 (0.38) | — | |
| SCHEMBL17076736 | 0.78 | ACHE (0.31) | — | |
| SCHEMBL26775818 | 0.78 | — | — | |
| SCHEMBL15894923 | 0.78 | JAK2 (0.39) | — | |
| SCHEMBL15894956 | 0.78 | JAK2 (0.39) | — | |
| SCHEMBL1662833 | 0.77 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3990449-A1 | HETEROCYCLIC COMPOUNDS FOR MEDIATING TYROSINE KINASE 2 ACTIVITY | Guangzhou InnoCare Pharma Tech Co., Ltd. (CN) | 2022-05-04 | — | — | EP | disclosed |
| WO-2020259584-A1 | HETEROCYCLIC COMPOUNDS FOR MEDIATING TYROSINE KINASE 2 ACTIVITY | GUANGZHOU INNOCARE PHARMA TECH CO., LTD. (CN) | 2020-12-30 | — | — | WO | disclosed |
| CN-104736533-B | Vegfr3 inhibitor | 癌症治疗合作研究中心有限公司 | 2016-12-07 | — | — | CN | disclosed |
| US-9238644-B2 | VEGFR3 inhibitors | CANCER THERAPEUTICS CRC PTY LIMITED (AU) | 2016-01-19 | — | — | US | disclosed |
| US-20160009686-A1 | VEGFR3 INHIBITORS | CANCER THERAPEUTICS CRC PTY LIMITED (AU) | 2016-01-14 | — | — | US | disclosed |
| CN-104736533-A | VEGFR3 inhibitors | CANCER THERAPEUTICS CRC PTY LTD | 2015-06-24 | — | — | CN | disclosed |
| US-20140073620-A1 | VEGFR3 INHIBITORS | CANCER THERAPEUTICS CRC PTY LIMITED (AU) | 2014-03-13 | — | — | US | disclosed |