SCHEMBL15514928

SCHEMBL15514928

C[C]1C(C)C1C1CN(c2ccc3[nH]ncc3c2)C1

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 5/20 0.46
ROCK2 O75116 10/20 0.45
JAK2 O60674 4/20 0.43
GSK3B P49841 4/20 0.43
PIM1 P11309 2/20 0.43
CYP2D6 P10635 7/20 0.42
SLC6A2 P23975 7/20 0.42
SLC6A4 P31645 7/20 0.42
SLC6A3 Q01959 7/20 0.42
ROCK1 Q13464 2/20 0.42
KDM4E B2RXH2 1/20 0.42
MEN1 O00255 1/20 0.42
ALDH1A1 P00352 1/20 0.42
GAA P10253 1/20 0.42
MAPT P10636 1/20 0.42
HPGD P15428 1/20 0.42
RAB9A P51151 1/20 0.42
KMT2A Q03164 1/20 0.42
HIF1A Q16665 1/20 0.42
TDP1 Q9NUW8 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15515585 0.82 ROCK2 (0.51) CYP3A4ROCK2JAK2GSK3BPIM1
SCHEMBL3204329 0.81 ROCK2 (0.54) CYP3A4ROCK2JAK2GSK3BPIM1
SCHEMBL24172739 0.72 CYP3A4 (0.58) CYP3A4ROCK2JAK2GSK3BCYP2D6
SCHEMBL15515501 0.72 CYP3A4 (0.58) CYP3A4ROCK2JAK2GSK3BROCK1
SCHEMBL2798618 0.70 CDC7 (0.59) CYP3A4ROCK2CYP2D6SLC6A2SLC6A4
SCHEMBL5823182 0.70 CYP3A4 (0.55) CYP3A4ROCK2JAK2GSK3BCYP2D6
SCHEMBL3190345 0.70 MAPT (0.49) CYP3A4ROCK2JAK2GSK3BCYP2D6
SCHEMBL17738851 0.69 CYP3A4 (0.58) CYP3A4ROCK2JAK2GSK3BPIM1
SCHEMBL30729087 0.69 CYP3A4 (0.58) CYP3A4ROCK2JAK2GSK3BPIM1
Hydrochloric Acid SCHEMBL22412381 0.69 CDC7 (0.58) CYP3A4ROCK2CYP2D6SLC6A2SLC6A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2892892-A1 IMIDAZOLIN-5-ONE DERIVATIVES USEFUL AS FATTY ACID SNTHASE (FASN) INHIBITORS FOR!THE TREATMENT OF CANCER Janssen Pharmaceutica N.V. (BE) 2015-07-15 EP disclosed
WO-2014039769-A1 IMIDAZOLIN-5-ONE DERIVATIVES USEFUL AS FATTY ACID SNTHASE (FASN) INHIBITORS FOR|THE TREATMENT OF CANCER JANSSEN PHARMACEUTICA NV (BE) 2014-03-13 WO disclosed