Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR1 | P21453 | 1/20 | 0.52 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.52 |
| ▸ | THRA | P10827 | 1/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | LPL | P06858 | 2/20 | 0.42 |
| ▸ | LIPG | Q9Y5X9 | 2/20 | 0.42 |
| ▸ | TLR8 | Q9NR97 | 4/20 | 0.40 |
| ▸ | GPR3 | P46089 | 1/20 | 0.40 |
| ▸ | EP300 | Q09472 | 1/20 | 0.39 |
| ▸ | KAT5 | Q92993 | 1/20 | 0.39 |
| ▸ | KAT8 | Q9H7Z6 | 1/20 | 0.39 |
| ▸ | HTR1A | P08908 | 1/20 | 0.39 |
| ▸ | HTR1D | P28221 | 1/20 | 0.39 |
| ▸ | HTR1B | P28222 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | ESR1 | P03372 | 1/20 | 0.39 |
| ▸ | SHBG | P04278 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11230398 | 0.91 | S1PR1 (0.56) | S1PR1S1PR3LPLLIPGTLR8 | |
| SCHEMBL15345306 | 0.84 | S1PR1 (0.53) | S1PR1S1PR3TLR8HTR1AHTR1D | |
| SCHEMBL15345355 | 0.84 | S1PR1 (0.53) | S1PR1S1PR3TLR8HTR1AHTR1D | |
| SCHEMBL15345397 | 0.81 | TLR8 (0.53) | S1PR1S1PR3TLR8 | |
| SCHEMBL15345485 | 0.81 | TLR8 (0.53) | S1PR1S1PR3TLR8 | |
| SCHEMBL28649207 | 0.80 | S1PR1 (0.47) | S1PR1S1PR3LPLLIPGTLR8 | |
| SCHEMBL27738335 | 0.80 | S1PR1 (0.47) | S1PR1S1PR3LPLLIPGTLR8 | |
| SCHEMBL9770069 | 0.79 | TLR8 (0.47) | S1PR1S1PR3LPLLIPGTLR8 | |
| SCHEMBL15515681 | 0.78 | THRA (0.49) | THRATHRBLPLLIPGTLR8 | |
| SCHEMBL31548020 | 0.78 | EP300 (0.46) | S1PR1S1PR3LPLLIPGEP300 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8673882-B2 | Inhibitors of autotaxin | UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION (US) | 2014-03-18 | — | — | US | disclosed |