Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK2 | O96017 | 17/20 | 0.70 |
| ▸ | DHODH | Q02127 | 1/20 | 0.58 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.50 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.50 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.50 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.50 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.47 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1552741 | 0.90 | CHEK2 (0.69) | CHEK2DHODH | |
| SCHEMBL1551751 | 0.88 | CHEK2 (0.85) | CHEK2DHODH | |
| SCHEMBL1551713 | 0.87 | CHEK2 (0.73) | CHEK2DHODH | |
| SCHEMBL5176542 | 0.86 | CHEK2 (0.53) | CHEK2DHODH | |
| SCHEMBL1552651 | 0.85 | CHEK2 (0.72) | CHEK2 | |
| SCHEMBL1552385 | 0.85 | CHEK2 (0.77) | CHEK2DHODH | |
| SCHEMBL1553042 | 0.85 | CHEK2 (0.67) | CHEK2 | |
| SCHEMBL1552781 | 0.84 | CHEK2 (0.65) | CHEK2DHODH | |
| SCHEMBL1552763 | 0.84 | CHEK2 (0.74) | CHEK2 | |
| SCHEMBL1551654 | 0.84 | CHEK2 (0.75) | CHEK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1824832-B1 | ARYL-SUBSTITUTED BENZIMIDAZOLE AND IMIDAZOPYRIDINE ETHERS AS ANTI-CANCER AGENTS | JANSSEN PHARMACEUTICA NV (BE) | 2011-04-27 | — | — | EP | claimed |