Known targets — ChEMBL curated mechanism
ADRA2AADRA2BADRA2CADRB2AGTR1AVPR1AAVPR1BAVPR2BDKRB2CALCRCHRNA3CHRNB4ESR1ESR2GHSRGNRHRGSC1HSPA8MALT1MC1RMC4RNOS1NOS2NOS3OPRK1OXTRRAMP1RAMP2RAMP3SCN5ASSTR1SSTR2SSTR3SSTR4SSTR5dacAdacBdacCfolPftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Acetic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.60 |
| ▸ | MEN1 | O00255 | 1/20 | 0.60 |
| ▸ | MAOB | P27338 | 8/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.58 |
| ▸ | CA12 | O43570 | 2/20 | 0.58 |
| ▸ | CA9 | Q16790 | 2/20 | 0.58 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.58 |
| ▸ | NT5E | P21589 | 1/20 | 0.58 |
| ▸ | HPGD | P15428 | 4/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.57 |
| ▸ | NPC1 | O15118 | 3/20 | 0.56 |
| ▸ | RAB9A | P51151 | 3/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.56 |
| ▸ | MAPT | P10636 | 2/20 | 0.56 |
| ▸ | GAA | P10253 | 1/20 | 0.56 |
| ▸ | CA1 | P00915 | 1/20 | 0.55 |
| ▸ | CA3 | P07451 | 1/20 | 0.55 |
| ▸ | TSHR | P16473 | 1/20 | 0.55 |
| ▸ | CA4 | P22748 | 1/20 | 0.55 |
| ▸ | CA6 | P23280 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL106241 | 0.92 | MEN1 (0.60) | KMT2AMEN1MAOBKDM4ECA12 | |
| Coumarin SCHEMBL18343641 | 0.92 | MCL1 (0.57) | KMT2AMEN1MAOBKDM4ECA12 | |
| SCHEMBL8881622 | 0.90 | MEN1 (0.58) | KMT2AMEN1MAOBKDM4ECA12 | |
| Hydrochloric Acid SCHEMBL11233384 | 0.90 | MEN1 (0.58) | KMT2AMEN1MAOBKDM4ECA12 | |
| SCHEMBL8881621 | 0.90 | MEN1 (0.58) | KMT2AMEN1MAOBKDM4ECA12 | |
| Fumaric Acid SCHEMBL27312330 | 0.90 | KMT2A (0.56) | KMT2AMEN1MAOBKDM4ECA12 | |
| Bicarbonate SCHEMBL4227922 | 0.84 | KDM4E (0.58) | KMT2AMEN1MAOBKDM4ECA12 | |
| SCHEMBL1045399 | 0.84 | KDM4E (0.61) | KMT2AMEN1MAOBKDM4ECA12 | |
| SCHEMBL28325417 | 0.83 | SMN1; SMN2 (0.73) | KMT2AMEN1MAOBKDM4ECA12 | |
| Methyl Alcohol SCHEMBL27953712 | 0.83 | KDM4E (0.59) | KMT2AMEN1MAOBKDM4ECA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 28 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116211966-A | Application of plant extract, novel coronavirus main protease inhibitor and screening method | 西北大学 | 2023-06-06 | — | — | CN | disclosed |
| US-20160257988-A1 | Indicator Molecules For Use In Detecting Enzyme Cleavage Activity | MOLOGIC LIMITED (GB) | 2016-09-08 | — | — | US | disclosed |
| EP-3060921-A1 | INDICATOR MOLECULES FOR USE IN DETECTING ENZYME CLEAVAGE ACTIVITY | Mologic Limited (GB) | 2016-08-31 | — | — | EP | disclosed |
| WO-2015059482-A1 | INDICATOR MOLECULES FOR USE IN DETECTING ENZYME CLEAVAGE ACTIVITY | MOLOGIC LIMITED (GB) | 2015-04-30 | — | — | WO | disclosed |
| US-8999644-B2 | Method for detecting the presence of a DNA minor contributor in a DNA mixture | CENTRE HOSPITALIER UNIVERSITAIRE VAUDOIS (CH) | 2015-04-07 | — | — | US | disclosed |
| EP-2635706-B1 | METHOD FOR DETECTING THE PRESENCE OF A DNA MINOR CONTRIBUTOR IN A DNA MIXTURE | CT HOSPITALIER UNIVERSITAIRE VAUDOIS (CH) | 2015-04-01 | — | — | EP | disclosed |
| US-20130260380-A1 | METHOD FOR DETECTING THE PRESENCE OF A DNA MINOR CONTRIBUTOR IN A DNA MIXTURE | CENTRE HOSPITALIER UNIVERSITAIRE VAUDOIS (CH) | 2013-10-03 | — | — | US | disclosed |
| EP-2635706-A1 | METHOD FOR DETECTING THE PRESENCE OF A DNA MINOR CONTRIBUTOR IN A DNA MIXTURE | Centre Hospitalier Universitaire Vaudois (CH) | 2013-09-11 | — | — | EP | disclosed |
| US-8501426-B2 | Method for identifying protease inhibitors | VERTEX PHARMACEUTICAL INCORPORATED (US) | 2013-08-06 | — | — | US | disclosed |
| WO-2012059888-A1 | METHOD FOR DETECTING THE PRESENCE OF A DNA MINOR CONTRIBUTOR IN A DNA MIXTURE | CENTRE HOSPITALIER UNIVERSITAIRE VAUDOIS (CH) | 2012-05-10 | — | — | WO | disclosed |
| EP-1864137-A2 | METHODS TO IDENTIFY AND CHARACTERIZE PROLYL OLIGO-PEPTIDASES BY USING SUBSTRATES AND PRODUCTS THEREOF | DIGILAB BioVisioN GmbH (DE) | 2007-12-12 | — | — | EP | disclosed |
| EP-1795606-A1 | Method for screening for proteases and their substrates | DIGILAB BioVisioN GmbH (DE) | 2007-06-13 | — | — | EP | disclosed |
| WO-2007039184-A2 | METHOD AND ANALYTICAL REAGENTS FOR IDENTIFYING THERAPEUTICS USING BIOMARKERS RESPONSIVE TO THIAZOLIDINEDIONES | DIGILAB, INC. (US) | 2007-04-12 | — | — | WO | disclosed |
| EP-1766416-A1 | USE OF STANDARDS FOR MONITORING ALTERATIONS OF PEPTIDE AND PROTEIN SAMPLES | DIGILAB BioVisioN GmbH (DE) | 2007-03-28 | — | — | EP | disclosed |
| US-20070037143-A1 | Method for screening for protease modulators | DIGILAB BIOVISION GMBH (DE) | 2007-02-15 | — | — | US | disclosed |
| WO-2007017293-A2 | METHOD FOR SCREENING FOR PROTEASES AND THEIR SUBSTRATES | DIGILAB BIOVISION GMBH (DE) | 2007-02-15 | — | — | WO | disclosed |
| EP-1741790-A1 | Methods to identify and characterize prolyl oligopeptidases by using substrates and products thereof | DIGILAB BioVisioN GmbH (DE) | 2007-01-10 | — | — | EP | disclosed |
| WO-2006100096-A2 | METHODS TO IDENTIFY AND CHARACTERIZE PROLYL OLIGO-PEPTIDASES BY USING SUBSTRATES AND PRODUCTS THEREOF | DIGILAB BIOVISION GMBH (DE) | 2006-09-28 | — | — | WO | disclosed |
| EP-1619503-A1 | Use of standards for monitoring alterations of peptide and protein samples | BioVisioN AG (DE) | 2006-01-25 | — | — | EP | disclosed |
| WO-2006005622-A1 | USE OF STANDARDS FOR MONITORING ALTERATIONS OF PEPTIDE AND PROTEIN SAMPLES | DIGILAB BIOVISION GMBH (DE) | 2006-01-19 | — | — | WO | disclosed |