Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.58 |
| ▸ | MAOB | P27338 | 5/20 | 0.58 |
| ▸ | CA12 | O43570 | 3/20 | 0.58 |
| ▸ | CA9 | Q16790 | 3/20 | 0.58 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.58 |
| ▸ | NT5E | P21589 | 1/20 | 0.58 |
| ▸ | CA1 | P00915 | 1/20 | 0.55 |
| ▸ | CA3 | P07451 | 1/20 | 0.55 |
| ▸ | TSHR | P16473 | 1/20 | 0.55 |
| ▸ | CA4 | P22748 | 1/20 | 0.55 |
| ▸ | CA6 | P23280 | 1/20 | 0.55 |
| ▸ | CA5A | P35218 | 1/20 | 0.55 |
| ▸ | CA7 | P43166 | 1/20 | 0.55 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.55 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.55 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.55 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.55 |
| ▸ | CD74 | P04233 | 1/20 | 0.54 |
| ▸ | MIF | P14174 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1045399 | 0.97 | KDM4E (0.61) | KDM4EMAOBCA12CA9CYP1A2 | |
| Methyl Alcohol SCHEMBL27953712 | 0.95 | KDM4E (0.59) | KDM4EMAOBCA12CA9CYP1A2 | |
| SCHEMBL6036799 | 0.87 | MAOB (0.58) | KDM4EMAOBCA12CA9CYP1A2 | |
| Acetic Acid SCHEMBL155186 | 0.84 | KMT2A (0.60) | KDM4EMAOBCA12CA9CYP1A2 | |
| SCHEMBL11075359 | 0.83 | KDM4E (0.60) | KDM4EMAOBCA12CA9CYP1A2 | |
| SCHEMBL27696165 | 0.83 | CA12 (0.65) | KDM4EMAOBCA12CA9CA1 | |
| SCHEMBL11081635 | 0.83 | HPGD (0.53) | KDM4EMAOBCA12CA9CYP1A2 | |
| SCHEMBL7537579 | 0.82 | POLB (0.54) | KDM4EMAOBCA12CA9CYP1A2 | |
| SCHEMBL8304474 | 0.80 | MAOB (0.59) | KDM4EMAOBCA12CA9CYP1A2 | |
| SCHEMBL5057152 | 0.80 | MAOB (0.52) | KDM4EMAOBCA12CA9CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1204430-B1 | CONJUGATES AND METHODS FOR THE PRODUCTION THEREOF, AND THEIR USE FOR TRANSPORTING MOLECULES VIA BIOLOGICAL MEMBRANES | SANOFI AVENTIS DEUTSCHLAND (DE) | 2009-11-04 | — | — | EP | disclosed |
| EP-1204430-A2 | CONJUGATES AND METHODS FOR THE PRODUCTION THEREOF, AND THEIR USE FOR TRANSPORTING MOLECULES VIA BIOLOGICAL MEMBRANES | Aventis Pharma Deutschland GmbH (DE) | 2002-05-15 | — | — | EP | disclosed |
| WO-2001008707-A2 | CONJUGATES AND METHODS FOR THE PRODUCTION THEREOF, AND THEIR USE FOR TRANSPORTING MOLECULES VIA BIOLOGICAL MEMBRANES | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2001-02-08 | — | — | WO | disclosed |