Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC | P12931 | 4/20 | 0.58 |
| ▸ | KDR | P35968 | 4/20 | 0.58 |
| ▸ | EGFR | P00533 | 4/20 | 0.58 |
| ▸ | ABL1 | P00519 | 4/20 | 0.58 |
| ▸ | PIK3CD | O00329 | 4/20 | 0.58 |
| ▸ | HCK | P08631 | 3/20 | 0.58 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.58 |
| ▸ | PIK3CB | P42338 | 3/20 | 0.58 |
| ▸ | MTOR | P42345 | 3/20 | 0.58 |
| ▸ | PIK3CG | P48736 | 3/20 | 0.58 |
| ▸ | EPHB4 | P54760 | 3/20 | 0.58 |
| ▸ | PRKDC | P78527 | 3/20 | 0.58 |
| ▸ | PI4KB | Q9UBF8 | 3/20 | 0.58 |
| ▸ | JAK2 | O60674 | 3/20 | 0.48 |
| ▸ | DYRK3 | O43781 | 2/20 | 0.48 |
| ▸ | CDK1 | P06493 | 2/20 | 0.48 |
| ▸ | ROS1 | P08922 | 2/20 | 0.48 |
| ▸ | RPS6KB1 | P23443 | 2/20 | 0.48 |
| ▸ | CDK2 | P24941 | 2/20 | 0.48 |
| ▸ | CSNK1A1 | P48729 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15519064 | 1.00 | SRC (0.58) | SRCKDREGFRABL1PIK3CD | |
| SCHEMBL13860324 | 1.00 | SRC (0.58) | SRCKDREGFRABL1PIK3CD | |
| SCHEMBL25678106 | 0.81 | JAK2 (0.53) | SRCKDREGFRABL1PIK3CD | |
| SCHEMBL3684615 | 0.80 | JAK2 (0.56) | SRCKDREGFRABL1PIK3CD | |
| SCHEMBL14617265 | 0.80 | ABL1 (0.64) | SRCKDREGFRABL1PIK3CD | |
| SCHEMBL25678092 | 0.80 | SRC (0.52) | SRCKDREGFRABL1PIK3CD | |
| SCHEMBL26061889 | 0.78 | SRC (0.58) | SRCKDREGFRABL1PIK3CD | |
| SCHEMBL28467319 | 0.76 | JAK2 (0.56) | SRCKDREGFRABL1PIK3CD | |
| SCHEMBL13860354 | 0.75 | EGFR (0.65) | SRCKDREGFRABL1PIK3CD | |
| SCHEMBL13860356 | 0.75 | EGFR (0.65) | SRCKDREGFRABL1PIK3CD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2892900-A1 | PYRAZOLOPYRIMIDINE COMPOUNDS AS KINASE INHIBITORS | Principia Biopharma Inc. (US) | 2015-07-15 | — | — | EP | disclosed |
| WO-2014039899-A1 | PYRAZOLOPYRIMIDINE COMPOUNDS AS KINASE INHIBITORS | PRINCIPIA BIOPHARMA INC. (US) | 2014-03-13 | — | — | WO | disclosed |