Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRN | P28799 | 3/20 | 0.50 |
| ▸ | SORT1 | Q99523 | 3/20 | 0.50 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.46 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | MAPK14 | Q16539 | 6/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | MAPK13 | O15264 | 2/20 | 0.41 |
| ▸ | MAPK12 | P53778 | 2/20 | 0.41 |
| ▸ | MAPK11 | Q15759 | 2/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.40 |
| ▸ | RAF1 | P04049 | 1/20 | 0.40 |
| ▸ | BRAF | P15056 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15516042 | 0.90 | GRN (0.49) | GRNSORT1SCN9AKLKB1ALDH1A1 | |
| SCHEMBL16749217 | 0.87 | GRN (0.53) | GRNSORT1SCN9AKLKB1ALDH1A1 | |
| SCHEMBL15517497 | 0.87 | GRN (0.46) | GRNSORT1SCN9AKLKB1ALDH1A1 | |
| SCHEMBL15517667 | 0.86 | GRN (0.46) | GRNSORT1SCN9AKLKB1ALDH1A1 | |
| SCHEMBL20028223 | 0.86 | KMT2A (0.53) | SCN9AALDH1A1POLBHTTLMNA | |
| SCHEMBL12705321 | 0.86 | GRN (0.68) | GRNSORT1ALDH1A1POLBGAA | |
| SCHEMBL4434009 | 0.85 | GRN (0.51) | GRNSORT1SCN9AALDH1A1POLB | |
| SCHEMBL16749337 | 0.85 | MAPK14 (0.53) | GRNSORT1SCN9AALDH1A1POLB | |
| SCHEMBL19750003 | 0.85 | SCN9A (0.46) | SCN9AALDH1A1POLBGAAHTT | |
| SCHEMBL15518413 | 0.84 | ALDH1A1 (0.50) | SCN9AALDH1A1POLBGAAHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10301288-B2 | Kinase inhibitors | TOPIVERT PHARMA LIMITED (GB) | 2019-05-28 | — | — | US | disclosed |
| US-20180086741-A1 | KINASE INHIBITORS | OXULAR ACQUISITIONS LIMITED (GB) | 2018-03-29 | — | — | US | disclosed |
| US-20180086741-A1 | KINASE INHIBITORS | OXULAR ACQUISITIONS LIMITED (GB) | 2018-03-29 | — | — | US | disclosed |
| US-9850233-B2 | Kinase inhibitors | RESPIVERT LIMITED (GB) | 2017-12-26 | — | — | US | disclosed |
| US-9850233-B2 | Kinase inhibitors | RESPIVERT LIMITED (GB) | 2017-12-26 | — | — | US | disclosed |
| US-9796742-B2 | Kinase inhibitors | RESPIVERT LIMITED (GB) | 2017-10-24 | — | — | US | disclosed |
| EP-2890460-B1 | KINASE INHIBITORS | RESPIVERT LTD (GB) | 2017-02-22 | — | — | EP | disclosed |
| US-20160340375-A1 | KINASE INHIBITORS | OXULAR ACQUISITIONS LIMITED (GB) | 2016-11-24 | — | — | US | disclosed |
| US-20160318909-A1 | KINASE INHIBITORS | OXULAR ACQUISITIONS LIMITED (GB) | 2016-11-03 | — | — | US | disclosed |
| US-20160318909-A1 | KINASE INHIBITORS | OXULAR ACQUISITIONS LIMITED (GB) | 2016-11-03 | — | — | US | disclosed |
| US-20160016934-A1 | KINASE INHIBITORS | TOPIVERT PHARMA LIMITED (GB) | 2016-01-21 | — | — | US | disclosed |
| US-20160016934-A1 | KINASE INHIBITORS | TOPIVERT PHARMA LIMITED (GB) | 2016-01-21 | — | — | US | disclosed |
| EP-2970190-A1 | KINASE INHIBITORS | Respivert Limited (GB) | 2016-01-20 | — | — | EP | disclosed |
| US-20150210722-A1 | KINASE INHIBITORS | RESPIVERT LIMITED (GB) | 2015-07-30 | — | — | US | disclosed |
| EP-2890460-A1 | KINASE INHIBITORS | Respivert Limited (GB) | 2015-07-08 | — | — | EP | disclosed |
| WO-2014140582-A1 | KINASE INHIBITORS | RESPIVERT LIMITED (GB) | 2014-09-18 | — | — | WO | disclosed |
| WO-2014033446-A1 | KINASE INHIBITORS | RESPIVERT LIMITED (GB) | 2014-03-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180086741-A1 | KINASE INHIBITORS | SYK, BTK, SRC | GRN 4443/4885SORT1 2896/4885SCN9A 1882/4885 |
| US-10301288-B2 | Kinase inhibitors | SYK, BTK, SRC | GRN 4443/4885SORT1 2896/4885SCN9A 1882/4885 |
| US-20160016934-A1 | KINASE INHIBITORS | SYK, LYN, BTK | GRN 4016/4885SORT1 2971/4885SCN9A 2150/4885 |
| US-20160318909-A1 | KINASE INHIBITORS | SYK, LYN, BTK | GRN 4049/4885SORT1 3073/4885SCN9A 2268/4885 |
| US-20150210722-A1 | KINASE INHIBITORS | SYK, SRC, LYN | GRN 3360/4885SORT1 3500/4885SCN9A 2569/4885 |
| US-20160340375-A1 | KINASE INHIBITORS | SYK, LYN, BTK | GRN 3218/4885SORT1 3481/4885SCN9A 2848/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.