Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 18/20 | 0.60 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9913951 | 0.94 | PDE5A (0.68) | PDE5AADORA3KCNH2 | |
| SCHEMBL15520402 | 0.91 | PDE5A (0.60) | PDE5AADORA3KCNH2 | |
| SCHEMBL9913961 | 0.89 | PDE5A (0.58) | PDE5AADORA3KCNH2 | |
| SCHEMBL9913925 | 0.85 | PDE5A (0.68) | PDE5AADORA3KCNH2 | |
| SCHEMBL29859877 | 0.84 | PDE5A (0.55) | PDE5A | |
| SCHEMBL326526 | 0.84 | PDE5A (0.55) | PDE5A | |
| SCHEMBL9913937 | 0.84 | PDE5A (0.54) | PDE5AADORA3KCNH2 | |
| SCHEMBL9913979 | 0.83 | PDE5A (0.65) | PDE5AADORA3KCNH2 | |
| SCHEMBL9914126 | 0.82 | PDE5A (0.52) | PDE5AADORA3KCNH2 | |
| SCHEMBL16245036 | 0.81 | PDE5A (0.63) | PDE5AADORA3KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2708539-A1 | Annulated pyrimidines and triazines and their use | Bayer Intellectual Property GmbH (DE) | 2014-03-19 | — | — | EP | disclosed |
| EP-2682394-A1 | 1H-pyrazolo[3,4-b]pyridin-triazine derivatives and their use for the treatment or the prevention of cardiovascular diseases | Bayer Intellectual Property GmbH (DE) | 2014-01-08 | — | — | EP | disclosed |