Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FAAH | O00519 | 18/20 | 0.52 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.52 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.41 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1000395 | 0.91 | FAAH (0.54) | FAAHKCNH2 | |
| SCHEMBL1002460 | 0.89 | FAAH (0.51) | FAAHKCNH2 | |
| SCHEMBL27903323 | 0.89 | FAAH (0.51) | FAAHKCNH2 | |
| SCHEMBL15520830 | 0.86 | FAAH (0.48) | FAAHKCNH2 | |
| SCHEMBL1000287 | 0.82 | FAAH (0.78) | FAAHKCNH2 | |
| SCHEMBL2365445 | 0.81 | FAAH (0.49) | FAAHKCNH2 | |
| SCHEMBL15520358 | 0.79 | FAAH (0.61) | FAAH | |
| SCHEMBL27903313 | 0.79 | FAAH (0.47) | FAAHKCNH2 | |
| SCHEMBL15520598 | 0.78 | FAAH (0.60) | FAAH | |
| SCHEMBL15520700 | 0.76 | FAAH (0.60) | FAAHKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2321288-B1 | OXAZOLE DERIVATIVES USEFUL AS INHIBITORS OF FAAH | MERCK SHARP & DOHME (US) | 2014-03-19 | — | — | EP | claimed |