Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 7/20 | 0.50 |
| ▸ | AXL | P30530 | 4/20 | 0.47 |
| ▸ | MERTK | Q12866 | 2/20 | 0.47 |
| ▸ | KDR | P35968 | 11/20 | 0.47 |
| ▸ | PDGFRA | P16234 | 6/20 | 0.47 |
| ▸ | KIT | P10721 | 2/20 | 0.43 |
| ▸ | AURKA | O14965 | 2/20 | 0.43 |
| ▸ | ABL1 | P00519 | 2/20 | 0.43 |
| ▸ | LCK | P06239 | 2/20 | 0.43 |
| ▸ | LYN | P07948 | 2/20 | 0.43 |
| ▸ | TEK | Q02763 | 2/20 | 0.43 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.43 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.43 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.43 |
| ▸ | EGFR | P00533 | 1/20 | 0.43 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.43 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.43 |
| ▸ | PGR | P06401 | 1/20 | 0.43 |
| ▸ | RET | P07949 | 1/20 | 0.43 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2200836 | 0.92 | AXL (0.47) | METAXLMERTKKDRPDGFRA | |
| SCHEMBL20525857 | 0.86 | KDR (0.50) | METAXLMERTKKDRPDGFRA | |
| SCHEMBL411650 | 0.83 | AXL (0.55) | METAXLMERTKKDRPDGFRA | |
| SCHEMBL371661 | 0.82 | AXL (0.52) | METAXLMERTKKDRPDGFRA | |
| SCHEMBL20525836 | 0.81 | AXL (0.49) | METAXLMERTKKDRPDGFRA | |
| SCHEMBL2364278 | 0.79 | KDR (0.52) | METKDRPDGFRAAURKAABL1 | |
| SCHEMBL28531404 | 0.78 | AXL (0.54) | METAXLMERTKKDRKIT | |
| SCHEMBL2203252 | 0.77 | KDR (0.48) | METAXLKDRPDGFRAKIT | |
| SCHEMBL411305 | 0.77 | AXL (0.50) | METAXLMERTKKDRKIT | |
| SCHEMBL28545923 | 0.76 | AXL (0.51) | METAXLMERTKKDRKIT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2392565-B1 | c-Met modulators and methods of use | EXELIXIS INC (US) | 2014-03-19 | — | — | EP | disclosed |