Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 7/20 | 0.48 |
| ▸ | PDGFRA | P16234 | 6/20 | 0.48 |
| ▸ | SRC | P12931 | 2/20 | 0.47 |
| ▸ | TGFBR1 | P36897 | 2/20 | 0.47 |
| ▸ | MET | P08581 | 5/20 | 0.47 |
| ▸ | KIT | P10721 | 1/20 | 0.46 |
| ▸ | AXL | P30530 | 1/20 | 0.46 |
| ▸ | AURKA | O14965 | 1/20 | 0.46 |
| ▸ | ABL1 | P00519 | 1/20 | 0.46 |
| ▸ | LCK | P06239 | 1/20 | 0.46 |
| ▸ | LYN | P07948 | 1/20 | 0.46 |
| ▸ | TEK | Q02763 | 1/20 | 0.46 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.46 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2364278 | 0.93 | KDR (0.52) | KDRPDGFRAMETAURKAABL1 | |
| SCHEMBL20525857 | 0.91 | KDR (0.50) | KDRPDGFRASRCMETKIT | |
| SCHEMBL372191 | 0.84 | AXL (0.49) | KDRPDGFRASRCTGFBR1MET | |
| SCHEMBL20525836 | 0.82 | AXL (0.49) | KDRPDGFRASRCMETKIT | |
| SCHEMBL3871200 | 0.82 | MET (0.47) | KDRPDGFRASRCTGFBR1MET | |
| SCHEMBL2332118 | 0.81 | MET (0.59) | KDRPDGFRAMETKITAXL | |
| SCHEMBL4419629 | 0.80 | KDR (0.46) | KDRPDGFRAMETKITAXL | |
| SCHEMBL4414994 | 0.79 | MET (0.58) | KDRPDGFRASRCMETKIT | |
| SCHEMBL372051 | 0.77 | KDR (0.46) | KDRPDGFRASRCTGFBR1MET | |
| SCHEMBL2200836 | 0.77 | AXL (0.47) | KDRPDGFRASRCMETKIT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2392565-B1 | c-Met modulators and methods of use | EXELIXIS INC (US) | 2014-03-19 | — | — | EP | disclosed |
| EP-2612853-A1 | c-Met modulators and methods of use | Exelixis Inc. (US) | 2013-07-10 | — | — | EP | disclosed |
| EP-2210607-B1 | N-[3-fluoro-4-({6-(methyloxy)-7-[(3-morpholin-4-ylpropyl)oxy]quinolin-4-yl}oxy)phenyl]-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide for the treatment of cancer | EXELIXIS INC (US) | 2011-08-17 | — | — | EP | disclosed |
| EP-2213661-B1 | c-Met Modulators and Methods of Use | EXELIXIS INC (US) | 2011-07-20 | — | — | EP | disclosed |