Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.42 |
| ▸ | KDR | P35968 | 3/20 | 0.42 |
| ▸ | FLT3 | P36888 | 2/20 | 0.42 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.42 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.42 |
| ▸ | LCK | P06239 | 1/20 | 0.42 |
| ▸ | CSF1R | P07333 | 1/20 | 0.42 |
| ▸ | PIM1 | P11309 | 1/20 | 0.42 |
| ▸ | PHKG2 | P15735 | 1/20 | 0.42 |
| ▸ | MARK3 | P27448 | 1/20 | 0.42 |
| ▸ | CLK2 | P49760 | 1/20 | 0.42 |
| ▸ | GSK3A | P49840 | 1/20 | 0.42 |
| ▸ | ITK | Q08881 | 1/20 | 0.42 |
| ▸ | MAP4K2 | Q12851 | 1/20 | 0.42 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.42 |
| ▸ | MARK2 | Q7KZI7 | 1/20 | 0.42 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.42 |
| ▸ | MINK1 | Q8N4C8 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15520117 | 0.94 | KDR (0.50) | MAPTKMT2ACHRNA7KDRFLT3 | |
| SCHEMBL15519984 | 0.89 | KDR (0.47) | MAPTKDRSRCMAOBPOLB | |
| SCHEMBL15519663 | 0.84 | KDR (0.54) | KDRFLT3MAP4K4PIM1PIM3 | |
| SCHEMBL15520441 | 0.81 | PDGFRB (0.52) | MAPTKMT2AKDRFLT3PARP1 | |
| SCHEMBL15520273 | 0.81 | MAPT (0.40) | MAPTKMT2ACHRNA7KDRFLT3 | |
| SCHEMBL15520315 | 0.79 | KDR (0.40) | MAPTKDRCHEK1SMN1; SMN2NPSR1 | |
| SCHEMBL15520749 | 0.78 | KDR (0.39) | KDRCHEK1NPSR1 | |
| SCHEMBL15520274 | 0.77 | MAPT (0.46) | MAPTKMT2ACHRNA7KDRLYN | |
| SCHEMBL15520684 | 0.77 | CHEK1 (0.42) | KMT2AKDRCHEK1 | |
| SCHEMBL15519936 | 0.75 | CHEK1 (0.39) | KMT2ACHEK1HDAC6PARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2294065-B1 | INDOLYL-PYRIDONE DERIVATIVES HAVING CHECKPOINT KINASE 1 INHIBITORY ACTIVITY | VERNALIS R&D LTD (GB) | 2014-03-19 | — | — | EP | disclosed |