Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | KDR | P35968 | 1/20 | 0.43 |
| ▸ | PARP1 | P09874 | 1/20 | 0.41 |
| ▸ | LYN | P07948 | 2/20 | 0.41 |
| ▸ | SRC | P12931 | 2/20 | 0.41 |
| ▸ | BTK | Q06187 | 1/20 | 0.41 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.41 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.39 |
| ▸ | NUAK1 | O60285 | 1/20 | 0.39 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15520120 | 0.92 | KDR (0.50) | MAPTCHRNA7KMT2AKDRPARP1 | |
| SCHEMBL15519987 | 0.87 | KDR (0.47) | MAPTCHRNA7KMT2AKDRPARP1 | |
| SCHEMBL15520330 | 0.81 | KDR (0.54) | KDRPARP1ADORA2AADORA1NUAK1 | |
| SCHEMBL15520318 | 0.78 | KDR (0.51) | KDRPARP1NUAK1 | |
| SCHEMBL15520271 | 0.77 | MAPT (0.42) | MAPTCHRNA7KMT2AKDRPARP1 | |
| SCHEMBL15520317 | 0.76 | KDR (0.39) | MAPTKDRNUAK1 | |
| SCHEMBL1750035 | 0.75 | MAPT (0.42) | MAPTCHRNA7KMT2AKDRPARP1 | |
| SCHEMBL15520751 | 0.75 | KDR (0.38) | MAPTKDRPARP1NUAK1 | |
| SCHEMBL5079376 | 0.74 | KDR (0.74) | MAPTCHRNA7KMT2AKDRPARP1 | |
| SCHEMBL15520686 | 0.74 | FFAR1 (0.37) | KDRPARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2294065-B1 | INDOLYL-PYRIDONE DERIVATIVES HAVING CHECKPOINT KINASE 1 INHIBITORY ACTIVITY | VERNALIS R&D LTD (GB) | 2014-03-19 | — | — | EP | disclosed |