Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 7/20 | 0.39 |
| ▸ | AURKA | O14965 | 3/20 | 0.33 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.30 |
| ▸ | GAA | P10253 | 2/20 | 0.30 |
| ▸ | CA12 | O43570 | 1/20 | 0.30 |
| ▸ | CA1 | P00915 | 1/20 | 0.30 |
| ▸ | CA2 | P00918 | 1/20 | 0.30 |
| ▸ | CA9 | Q16790 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 2/20 | 0.30 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15520809 | 0.86 | KDR (0.41) | KDRAURKAKDM4EKMT2AMEN1 | |
| SCHEMBL15520077 | 0.82 | KDR (0.39) | KDRAURKAMCHR1KDM4EKMT2A | |
| SCHEMBL15520073 | 0.80 | KDR (0.40) | KDRKDM4EKMT2ACHEK1HSD17B10 | |
| SCHEMBL15520726 | 0.79 | KDR (0.38) | KDRAURKAKDM4EMAPTHSD17B10 | |
| SCHEMBL15520074 | 0.78 | KDR (0.35) | KDRAURKAMCHR1KDM4EKMT2A | |
| SCHEMBL15520713 | 0.73 | KDR (0.47) | KDRAURKACHEK1 | |
| SCHEMBL15520463 | 0.72 | KDR (0.49) | KDRAURKACHEK1PDGFRBPDGFRA | |
| SCHEMBL15520664 | 0.71 | KDR (0.37) | KDRAURKAKDM4EMAPTHSD17B10 | |
| SCHEMBL15520458 | 0.70 | KDR (0.59) | KDRAURKAKDM4EKMT2AMEN1 | |
| SCHEMBL4020830 | 0.69 | KDR (0.42) | KDRAURKAKDM4EHSD17B10CA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2294065-B1 | INDOLYL-PYRIDONE DERIVATIVES HAVING CHECKPOINT KINASE 1 INHIBITORY ACTIVITY | VERNALIS R&D LTD (GB) | 2014-03-19 | — | — | EP | claimed |