Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 10/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | SCD | O00767 | 3/20 | 0.35 |
| ▸ | SCD5 | Q86SK9 | 3/20 | 0.35 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.35 |
| ▸ | RPS6KA2 | Q15349 | 2/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | KDR | P35968 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15520202 | 1.00 | CHEK1 (0.38) | CHEK1POLBKDM4EMEN1KMT2A | |
| SCHEMBL15520771 | 0.92 | CHEK1 (0.36) | CHEK1RPS6KA3RPS6KA2KDR | |
| SCHEMBL15520721 | 0.89 | CHEK1 (0.43) | CHEK1KDR | |
| SCHEMBL949116 | 0.89 | RPS6KA2 (0.45) | CHEK1SCDSCD5RPS6KA3RPS6KA2 | |
| SCHEMBL949345 | 0.89 | RPS6KA2 (0.45) | CHEK1SCDSCD5RPS6KA3RPS6KA2 | |
| SCHEMBL15520299 | 0.89 | CHEK1 (0.48) | CHEK1 | |
| SCHEMBL15520312 | 0.87 | CHEK1 (0.50) | CHEK1KDR | |
| SCHEMBL15520361 | 0.86 | CHEK1 (0.38) | CHEK1SCDSCD5RPS6KA2 | |
| SCHEMBL15520680 | 0.81 | KDR (0.38) | CHEK1KDM4EMEN1KMT2ASCD | |
| SCHEMBL15520814 | 0.81 | KDR (0.39) | CHEK1KDM4EMEN1KMT2ASCD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2294065-B1 | INDOLYL-PYRIDONE DERIVATIVES HAVING CHECKPOINT KINASE 1 INHIBITORY ACTIVITY | VERNALIS R&D LTD (GB) | 2014-03-19 | — | — | EP | claimed |